US 11,964,989 B2
KRas G12D inhibitors
Xiaolun Wang, San Diego, CA (US); Aaron Craig Burns, San Diego, CA (US); James Gail Christensen, San Diego, CA (US); John Michael Ketcham, San Diego, CA (US); John David Lawson, Carlsbad, CA (US); Matthew Arnold Marx, San Diego, CA (US); Christopher Ronald Smith, San Diego, CA (US); Shelley Allen, Boulder, CO (US); James F. Blake, Longmont, CO (US); Mark Joseph Chicarelli, Boulder, CO (US); Joshua Ryan Dahlke, Longmont, CO (US); Donghua Dai, Superior, CO (US); Jay Bradford Fell, Longmont, CO (US); John Peter Fischer, Longmont, CO (US); Macedonio J. Mejia, Denver, CO (US); Brad Newhouse, Boulder, CO (US); Phong Nguyen, Boulder, CO (US); Jacob Matthew O'Leary, Denver, CO (US); Spencer Pajk, Boulder, CO (US); Martha E. Rodriguez, Boulder, CO (US); Pavel Savechenkov, Boulder, CO (US); Tony P. Tang, Boulder, CO (US); Guy P.A. Vigers, Boulder, CO (US); Qian Zhao, Boulder, CO (US); Dean Russell Kahn, Boulder, CO (US); John Gaudino, Boulder, CO (US); and Michael Christopher Hilton, Boulder, CO (US)
Assigned to Mirati Therapeutics, Inc., San Diego, CA (US); and Array BioPharma Inc., Boulder, CO (US)
Filed by Mirati Therapeutics, Inc., San Diego, CA (US); and Array BioPharma Inc., Boulder, CO (US)
Filed on Jul. 20, 2022, as Appl. No. 17/869,575.
Application 17/869,575 is a continuation of application No. 17/005,004, filed on Aug. 27, 2020, granted, now 11,453,683.
Claims priority of provisional application 63/058,188, filed on Jul. 29, 2020.
Claims priority of provisional application 63/052,840, filed on Jul. 16, 2020.
Claims priority of provisional application 62/893,604, filed on Aug. 29, 2019.
Prior Publication US 2023/0077225 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 519/00 (2006.01)
CPC C07D 519/00 (2013.01) 19 Claims
 
1. A compound selected from:

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and pharmaceutically acceptable salts thereof.