US 11,964,281 B2
System and method for correcting patient index
Henry Tat Kwong Tse, San Francisco, CA (US); Ajay M. Shah, San Francisco, CA (US); Lionel Guillou, San Francisco, CA (US); Roya Sheybani, San Francisco, CA (US); Audun Johnson, San Francisco, CA (US); Peter Landwehr, San Francisco, CA (US); and Hunter Stevenson, San Francisco, CA (US)
Assigned to CytoVale Inc., San Francisco, CA (US)
Filed by CytoVale Inc., San Francisco, CA (US)
Filed on Feb. 3, 2022, as Appl. No. 17/592,040.
Prior Publication US 2023/0241612 A1, Aug. 3, 2023
Int. Cl. B01L 3/00 (2006.01); G01N 33/50 (2006.01); G06T 7/00 (2017.01)
CPC B01L 3/502761 (2013.01) [B01L 3/502715 (2013.01); G01N 33/5094 (2013.01); G06T 7/0012 (2013.01); B01L 2200/0663 (2013.01); B01L 2300/0654 (2013.01); G06T 2207/30024 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for determining a sepsis condition of a subject comprising:
receiving a dataset generated from a blood sample of the subject, wherein the dataset comprises, for each leukocyte of the blood sample, a plurality of images of the leukocyte as the leukocyte is deformed within a deformation region of a microfluidic channel;
filtering the dataset to exclude images comprising overlapping leukocytes, comprising detecting the overlapping leukocytes based on a monotonicity in feature motion between images of the leukocyte;
determining a biophysical parameter dataset by, for each leukocyte of the blood sample:
determining one or more biophysical parameter associated with the respective leukocyte based on the plurality of images associated with the respective leukocyte;
linearly adjusting the one or more biophysical parameters based on at least one of a flow rate and a path traversed by the respective leukocyte; and
determining a numerical index based on the biophysical parameter dataset; and
based on the numerical index, determining a probability that the subject is experiencing sepsis.