US 11,964,250 B2
Multicompartment capsules and methods and systems for forming same
Hyuntaek Oh, College Park, MD (US); Srinivasa R. Raghavan, Columbia, MD (US); William E. Bentley, Annapolis, MD (US); Xi Lu, Abingdon, MD (US); Jessica Lynn Terrell, Philadelphia, PA (US); and So Hyun Ahn, College Park, MD (US)
Appl. No. 16/639,152
Filed by University of Maryland, College Park, College Park, MD (US)
PCT Filed Aug. 14, 2018, PCT No. PCT/US2018/046639
§ 371(c)(1), (2) Date Feb. 14, 2020,
PCT Pub. No. WO2019/036435, PCT Pub. Date Feb. 21, 2019.
Claims priority of provisional application 62/545,683, filed on Aug. 15, 2017.
Prior Publication US 2020/0171456 A1, Jun. 4, 2020
Int. Cl. B01J 13/22 (2006.01); B01J 13/10 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); A61K 35/12 (2015.01)
CPC B01J 13/22 (2013.01) [B01J 13/10 (2013.01); C12M 23/34 (2013.01); C12M 25/16 (2013.01); A61K 2035/128 (2013.01)] 11 Claims
 
1. A method of synthesizing a multicompartment capsule, comprising the steps of:
I. forming at least one plurality of polymer capsules via a capsule-forming process, wherein said capsule-forming process comprises:
A. providing a feed solution comprising a biopolymer;
B. providing a reservoir solution comprising a biopolymer, wherein said feed solution biopolymer and said reservoir solution biopolymer have opposite charges; and
C. introducing droplets of said feed solution into said reservoir solution, thereby forming via electrostatic complexation a plurality of polymer capsules;
II. encapsulating at least one polymer capsule(s) from said formed plurality of polymer capsules in an outer polymer shell, comprising:
A. providing a feed solution comprising a biopolymer and at least one polymer capsule(s) from said formed plurality of polymer capsules;
B. providing a reservoir solution comprising a biopolymer, wherein said feed solution biopolymer and said reservoir solution biopolymer have opposite charges; and
C. introducing droplets of said feed solution into said reservoir solution, thereby forming via electrostatic complexation a plurality of outer polymer shells, wherein at least one of said outer polymer shells encapsulates said at least one polymer capsule(s), thereby forming a multicompartment capsule,
wherein said feed solution of either of steps I (A) or II (A) further comprises a payload, wherein at least one polymer capsule(s) from savid formed polymer capsules encapsulates said payload.