	US 11,964,076 B2
	Multi-layered polymer film for sustained release of agents
Honglei Wang, Singapore (SG); and Jingnan Luo, Singapore (SG)
Assigned to Foundry Therapeutics, Inc., Menlo Park, CA (US)
Filed by Foundry Therapeutics, Inc., Menlo Park, CA (US)
Filed on Jul. 15, 2021, as Appl. No. 17/305,851.
Application 17/305,851 is a continuation of application No. 16/366,323, filed on Mar. 27, 2019, abandoned.
Application 16/366,323 is a continuation of application No. 15/563,527, abandoned, previously published as PCT/SG2016/050158, filed on Mar. 31, 2016.
Claims priority of application No. 1505527 (GB), filed on Mar. 31, 2015.
Prior Publication US 2022/0072207 A1, Mar. 10, 2022
Int. Cl. A61L 31/16 (2006.01); A61K 31/496 (2006.01); A61K 31/65 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61L 31/04 (2006.01); A61L 31/06 (2006.01); A61L 31/14 (2006.01); A61N 1/375 (2006.01); A61P 31/00 (2006.01)

CPC A61L 31/16 (2013.01) [A61K 31/496 (2013.01); A61K 31/65 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 31/041 (2013.01); A61L 31/06 (2013.01); A61L 31/148 (2013.01); A61N 1/375 (2013.01); A61P 31/00 (2018.01); A61L 2300/404 (2013.01); A61L 2300/406 (2013.01); A61L 2300/602 (2013.01)]

20 Claims

1. A method for manufacturing an implantable film including an upper film layer, an intermediate film layer, and a lower film layer, the method comprising:

forming the intermediate film layer by:

combining poly(lactide-co-glycolide) (PLGA), a releasing agent, and an active agent in a solvent, and

evaporating the solvent to form the intermediate film layer, wherein the active agent constitutes from 40 wt % to 80 wt % of the intermediate film layer;

forming the upper film layer on an upper surface of the intermediate film layer by dip coating, wherein the upper film layer includes PLGA and is configured to control release of the active agent from the intermediate film layer; and

forming the lower film layer on a lower surface of the intermediate film layer by dip coating, wherein the lower film layer includes PLGA and is configured to control release of the active agent from the intermediate film layer.