US 11,964,019 B2
Cochleates made with soy phosphatidylserine
Raphael Mannino, Glen Gardner, NJ (US); and Ruying Lu, New Providence, NJ (US)
Assigned to Rutgers, The State University of New Jersey, New Brunswick, NJ (US); and Matinas BioPharma Nanotechnologies, Inc., Bedminster, NJ (US)
Filed by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US); and MATINAS BIOPHARMA NANOTECHNOLOGIES, INC., Bedminster, NJ (US)
Filed on Jun. 18, 2020, as Appl. No. 16/904,824.
Application 16/904,824 is a continuation of application No. 15/811,040, filed on Nov. 13, 2017, granted, now 10,716,860.
Application 15/811,040 is a continuation of application No. 14/418,392, abandoned, previously published as PCT/US2013/052756, filed on Jul. 30, 2013.
Claims priority of provisional application 61/835,825, filed on Jun. 17, 2013.
Claims priority of provisional application 61/677,414, filed on Jul. 30, 2012.
Prior Publication US 2021/0038722 A1, Feb. 11, 2021
Int. Cl. A61K 47/24 (2006.01); A61K 9/127 (2006.01); A61K 9/19 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/685 (2006.01); A61K 31/7036 (2006.01); A61K 31/7048 (2006.01); A61K 33/06 (2006.01); A61K 45/06 (2006.01); A61K 47/02 (2006.01)
CPC A61K 47/24 (2013.01) [A61K 9/1274 (2013.01); A61K 9/1277 (2013.01); A61K 9/19 (2013.01); A61K 31/12 (2013.01); A61K 31/122 (2013.01); A61K 31/685 (2013.01); A61K 31/7036 (2013.01); A61K 31/7048 (2013.01); A61K 33/06 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01)] 13 Claims
 
1. A method for preparing cochleates comprising:
(a) providing a suspension of liposomes in an aqueous medium, wherein the liposomes comprise (i) a lipid bilayer comprising soy phosphatidylserine in an amount of about 40%-55% by weight of the lipid bilayer, and (ii) a bioactive drug;
(b) contacting the suspension of liposomes of (a) with a multivalent cation,
thereby preparing cochleates.