US 11,963,808 B2
In vivo measurement system and method for the localized measurement of radiotracer concentration in the body
Joshua G. Knowland, Cary, NC (US); Ronald K. Lattanze, Morrisville, NC (US); Paul Mozley, Collegeville, PA (US); and Steven Perrin, Durham, NC (US)
Assigned to Lucerno Dynamics, LLC, Cary, NC (US)
Filed by Lucerno Dynamics, LLC, Cary, NC (US)
Filed on May 21, 2021, as Appl. No. 17/326,445.
Prior Publication US 2022/0370024 A1, Nov. 24, 2022
Int. Cl. A61B 6/00 (2006.01); A61B 6/40 (2024.01); A61B 6/42 (2024.01); A61B 6/50 (2024.01)
CPC A61B 6/4057 (2013.01) [A61B 6/425 (2013.01); A61B 6/4258 (2013.01); A61B 6/4429 (2013.01); A61B 6/48 (2013.01); A61B 6/50 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A device for localized measurement of radiotracers in a blood vessel of interest, the device comprising:
a cannula sized and configured for insertion into the blood vessel of interest, the cannula comprising a measurement chamber portion of known volume extending substantially between a first opening proximate a distal end of the cannula, and a second opening disposed in a sidewall of the cannula, wherein the second opening is sized to allow blood from the blood vessel of interest to enter and flow through the measurement chamber portion and exit the first opening of the cannula;
a radiation detector positioned proximate the measurement chamber for detecting radiation emitted from blood within the measurement chamber.
 
16. A device for localized measurement of radiotracers in the body, the device comprising:
a cannula sized and configured for insertion into a blood vessel of interest, the cannula comprising a measurement chamber portion of known volume extending substantially between a first opening at a distal end of the cannula, and a second opening disposed in a sidewall of the cannula, wherein the second opening is sized to allow blood from the blood vessel of interest to enter and flow through the measurement chamber portion to the first opening of the cannula;
a scintillation material disposed about the measurement chamber portion, wherein the scintillation material emits light when impacted with particles emitted from a radioactive material.