US 11,963,750 B2
Systems, devices and methods for non-invasive hematological measurements
Carlos Castro-Gonzalez, Cambridge, MA (US); Ian Butterworth, Somerville, MA (US); Aurelien Bourquard, Madrid (ES); Alvaro Sanchez Ferro, Madrid (ES); Jason Tucker-Schwartz, Melrose, MA (US); Alberto Pablo Trinidad, Madrid (ES); Maria J. Ledesma Carbayo, Madrid (ES); and Tom Vettenburg, Dundee (GB)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and Universidad Politecnica De Madrid, Madrid (ES)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and Universidad Politecnica De Madrid, Madrid (ES)
Filed on Feb. 7, 2022, as Appl. No. 17/666,461.
Application 17/666,461 is a continuation of application No. 16/162,006, filed on Oct. 16, 2018, granted, now 11,244,452.
Claims priority of provisional application 62/572,738, filed on Oct. 16, 2017.
Prior Publication US 2022/0254024 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G06K 9/00 (2022.01); A61B 5/00 (2006.01); A61B 5/026 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); G06T 7/00 (2017.01); G06V 40/10 (2022.01); G06V 40/14 (2022.01)
CPC A61B 5/0261 (2013.01) [A61B 5/14546 (2013.01); A61B 5/1455 (2013.01); A61B 5/489 (2013.01); A61B 5/6826 (2013.01); A61B 5/7203 (2013.01); A61B 5/7267 (2013.01); G06T 7/0014 (2013.01); G06V 40/10 (2022.01); A61B 2576/02 (2013.01); G06T 2207/10016 (2013.01); G06T 2207/10152 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30101 (2013.01); G06V 40/14 (2022.01); G06V 40/15 (2022.01); Y02A 90/10 (2018.01)] 27 Claims
OG exemplary drawing
 
1. A method of detecting neutropenia in a user, comprising:
acquiring a set of images of a capillary bed of a body portion of the user;
detecting, without manual input, in one or more images of the set of images, one or more capillaries of the body portion; and
classifying the user to a first user type of a set of user types, at least one user type of the set of user types associated with a diagnosis of neutropenia, the classifying based on:
an event count based on a set of cellular events in the one or more capillaries, each cellular event of the set of cellular events associated with passage of one or more types of white blood cells (WBCs) in a capillary of the one or more capillaries; and
an event count threshold associated with a minimum number of cellular events for classification of the user to the first user type, wherein the one or more capillaries comprises those capillaries having a diameter selected to be approximately equal to or less than a diameter of any WBC of the one or more types of WBCs for the user.