US 11,948,788 B2
TOF mass calibration
Robert E. Haufler, Toronto (CA); William M. Loyd, Sugar Land, TX (US); and Takashi Baba, Richmond Hill (CA)
Assigned to DH Technologies Development Pte. Ltd., Singapore (SG)
Appl. No. 17/310,989
Filed by DH TECHNOLOGIES DEVELOPMENT PTE. LTD., Singapore (SG)
PCT Filed Jun. 10, 2020, PCT No. PCT/IB2020/055464
§ 371(c)(1), (2) Date Sep. 3, 2021,
PCT Pub. No. WO2020/250157, PCT Pub. Date Dec. 17, 2020.
Claims priority of provisional application 62/860,300, filed on Jun. 12, 2019.
Prior Publication US 2022/0093383 A1, Mar. 24, 2022
Int. Cl. H01J 49/40 (2006.01); H01J 49/00 (2006.01)
CPC H01J 49/40 (2013.01) [H01J 49/0031 (2013.01); H01J 49/0036 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A mass calibration apparatus for a mass analyzer, comprising:
an ion source device of a mass spectrometer for ionizing an analyte of a sample, producing analyte ions; and
a dual-purpose electron beam generating unit of the mass spectrometer located between the ion source device and a mass analyzer of the mass spectrometer that,
in a first mode, when the mass spectrometer is in mass spectrometry (MS) mode, transmits the analyte ions to the mass analyzer directly or through one or more other units of the mass spectrometer for mass analysis or, when the mass spectrometer is in mass spectrometry/mass spectrometry (MS/MS) mode, fragments the analyte ions into product ions and transmits the product ions to the mass analyzer directly or through the one or more other units for mass analysis or transmits the analyte ions to a collision cell of the mass spectrometer for fragmentation that, in turn, transmits resulting product ions to the mass analyzer for mass analysis, and,
in a second mode, creates ions of calibration compounds and transmits the calibration ions to the mass analyzer directly or through the one or more other units for mass analysis.