CPC C07K 14/47 (2013.01) [C12N 15/62 (2013.01); C12N 15/79 (2013.01); G01N 33/5008 (2013.01); G01N 2800/28 (2013.01)] | 14 Claims |
1. A nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein; wherein the light-induced oligomerization domain is CRY2OLIG, or a fragment thereof and wherein the low complexity domain from a neurodegenerative disease target protein is TDP-43.
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