CPC A61K 39/145 (2013.01) [C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/1058 (2013.01); C12N 15/1072 (2013.01); C12N 2760/16121 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16162 (2013.01)] | 9 Claims |
1. A composition of matter, comprising:
a genetically engineered influenza A virus genome comprises a combination of nucleotide mutations at more than two amino acid positions selected from:
at least one amino acid substitution in SEQ ID NO: 3 at amino acid position N9, Q75 or T76; and/or
at least one amino acid substitution in SEQ ID NO: 5 at amino acid position N36, R72 or S225.
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