US 11,942,209 B2
Methods, systems, and apparatus for optimizing effects of treatment with medication using medication compliance patterns
Steven L. Mayer, Salem, WI (US); David C. Kravitz, Barrington Hills, IL (US); and Tracey H. Mayer, Salem, WI (US)
Assigned to I.D. THERAPEUTICS LLC, Salem, WI (US)
Filed by I.D. THERAPEUTICS LLC, Salem, WI (US)
Filed on Oct. 22, 2018, as Appl. No. 16/166,601.
Application 16/166,601 is a continuation of application No. 13/427,389, filed on Mar. 22, 2012, abandoned.
Application 13/427,389 is a continuation in part of application No. 12/888,133, filed on Sep. 22, 2010, abandoned.
Prior Publication US 2019/0057765 A1, Feb. 21, 2019
Int. Cl. G16H 20/10 (2018.01); G16H 20/13 (2018.01); G16H 20/70 (2018.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.01)
CPC G16H 20/70 (2018.01) [G16H 20/10 (2018.01); G16H 20/13 (2018.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.02); Y02A 90/10 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A method of optimizing treatment of a medication recipient patient, comprising:
administering at least one active medication to the patient as a part of a medication treatment regimen, wherein the at least one active medication is selected from the group consisting of cyclosporine, azathioprine, prednisone, tacrolimus, mycophenolate mofetil, sirolimus, methotrexate, leflunomide, cyclophosphamide, chlorambucil and nitrogen mustard;
providing the patient with a reprogrammable medication monitor capable of providing usage data regarding the patient's compliance with the medication treatment regimen, the medication treatment regimen being established based on a medication compliance pattern of the patient, wherein the compliance pattern is a statistical pattern derived from a plurality of data points gathered over a period of time of not less than one week, where the data points include doses missed, doses taken early, doses taken late, and taken on time,
the medication monitor including:
a housing body that includes a housing for containing medication or medication packaging, the housing body defining an opening to accommodate insertion and removal of the medication or of the medication packaging, and
a removal sensor that senses at least one of (1) removal of the medication or of the medication packaging and (ii) opening of the housing body;
collecting the usage data from the medication monitor at a central server over a predetermined period of time; determining safety and efficacy of the medication treatment regimen;
determining the patient's pattern of compliance with the medication treatment regimen based on the usage data collected from the medication monitor;
obtaining diagnostic test results from a biomarker device, the diagnostic test results being indicative of a level of immunosuppression of the patient to the medication treatment regimen over the predetermined period of time,
the biomarker device being configured to be implanted in the patient or provided external to the patient;
correlating the patient's pattern of compliance and the patient's diagnostic test results with patterns of compliance and diagnostic test results from a population of patients to obtain a correlation;
outputting at least one recommendation based on the correlation and based on the safety and efficacy of the medication treatment regimen, the at least one recommendation including replacing the at least one active medication used in the medication treatment regimen with at least one different medication; and
adjusting and administering the medication treatment regimen of the patient based on the at least one recommendation.