US 11,940,508 B1
Magnetic particle imaging (MPI) and fluorescence molecular tomography (FMT)-fused multimodal imaging system for small animal
Jie Tian, Beijing (CN); Lishuang Guo, Beijing (CN); Jiangang Liu, Beijing (CN); and Yu An, Beijing (CN)
Assigned to Beijing University of Aeronautics and Astronautics, Beijing (CN)
Filed by Beijing University of Aeronautics and Astronautics, Beijing (CN)
Filed on Nov. 1, 2023, as Appl. No. 18/500,093.
Claims priority of application No. 202310070551.4 (CN), filed on Feb. 7, 2023.
Int. Cl. G01R 33/12 (2006.01); A61B 5/00 (2006.01); A61B 5/0515 (2021.01); G01R 33/00 (2006.01); G01R 33/10 (2006.01); G01R 33/385 (2006.01)
CPC G01R 33/1276 (2013.01) [A61B 5/0073 (2013.01); A61B 5/0515 (2013.01); G01R 33/0023 (2013.01); G01R 33/10 (2013.01); G01R 33/385 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A magnetic particle imaging (MPI) and fluorescence molecular tomography (FMT)-fused multimodal imaging system for a small animal, comprising an image processing module, a display module, a control module, an object table, a gradient coil, a driving coil, a reception coil, a fluorescence camera, and a light source module, wherein
the gradient coil comprises a first rounded rectangular coil and a second rounded rectangular coil; the first rounded rectangular coil and the second rounded rectangular coil are located on a same horizontal plane that serves as a first horizontal plane; the first rounded rectangular coil and the second rounded rectangular coil are arranged with respective long sides opposite, short sides flush, and axes parallel, and are symmetrically distributed at two sides of a longitudinal axis at a center of the object table; and the gradient coil is configured to construct a static field free line (FFL), such that magnetic particles around the FFL are saturated to form a gradient field in a space;
the driving coil comprises a third rounded rectangular coil, a fourth rounded rectangular coil, and a fifth rounded rectangular coil; the third rounded rectangular coil, the fourth rounded rectangular coil, and the fifth rounded rectangular coil are located on a same horizontal plane that serves as a second horizontal plane; the second horizontal plane is parallel to the first horizontal plane; the third rounded rectangular coil, the fourth rounded rectangular coil, and the fifth rounded rectangular coil are arranged with respective long sides parallel and short sides flush; a center of the third rounded rectangular coil and the center of the object table are located on a same longitudinal axis; the fourth rounded rectangular coil and the fifth rounded rectangular coil are located at two sides of the third rounded rectangular coil, and have a same distance to the third rounded rectangular coil; and the driving coil is configured to counteract a magnetic field of the gradient coil so as to control the FFL to make translational motion;
the reception coil is a circular coil provided directly below the object table and above the gradient coil; and the reception coil is configured to acquire a nonlinear response signal of the magnetic particles;
the fluorescence camera is provided directly above the object table to perform real-time imaging of a target object placed on the object table;
the light source module is fixed at a periphery of a fluorescence lens of the fluorescence camera to control an imaging mode of the fluorescence camera; and
the image processing module is configured to process an image acquired by the real-time imaging of the fluorescence camera as a first image, process and reconstruct the nonlinear response signal acquired by the reception coil as a second image, and fuse the first image and the second image to generate a final imaging result.