US 11,939,612 B2
Process for preparing sphingolipids
Marrit Friederike Eckstein, Essen (DE); Monica Desiree van Logchem, Zevenbergen (NL); Hans Henning Wenk, Mülheim an der Ruhr (DE); Annika Schrader, Bremen (DE); Ursula Maczkiewitz, Essen (DE); Claudia Hierath, Essen (DE); Sunay Karacocuk, Herne (DE); and Andreas Seifert, Bottrop (DE)
Assigned to Evonik Operations GmbH, Essen (DE)
Filed by Evonik Operations GmbH, Essen (DE)
Filed on Oct. 8, 2021, as Appl. No. 17/497,484.
Application 17/497,484 is a division of application No. 16/355,981, filed on Mar. 18, 2019, granted, now 11,155,842.
Claims priority of application No. 18164835 (EP), filed on Mar. 29, 2018.
Prior Publication US 2022/0025417 A1, Jan. 27, 2022
Int. Cl. C12P 13/02 (2006.01); A61K 8/68 (2006.01); A61K 8/92 (2006.01); A61Q 5/12 (2006.01); A61Q 19/00 (2006.01); C07H 15/00 (2006.01)
CPC C12P 13/02 (2013.01) [A61K 8/68 (2013.01); A61K 8/92 (2013.01); C07H 15/00 (2013.01); A61Q 5/12 (2013.01); A61Q 19/00 (2013.01); C12Y 301/01003 (2013.01)] 9 Claims
 
1. A cosmetic formulation comprising a composition, comprising:
A) at least one sphingolipid of the general formula I

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B) at least one lysosphingolipid of the general formula II

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C) at least one triglyceride of the general formula III

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D) at least one diglyceride of the general formula IV

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E) at least one monoglyceride of the general formula V

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where
R1 is the same or different and independently represents a linear or branched alkyl chain having 2 to 55 carbon atoms that optionally contains one or more multiple bonds and/or aromatic or heteroaromatic rings, is optionally interrupted by oxygen atoms or ester or amide functionalities and is optionally substituted by at least one further group selected from alkyl, hydroxyl, keto or amine groups,
R2 is the same or different and independently represents H, phosphocholine, serine, ethanolamine or a sugar, and
X represents CH═CH, CH2—CH2 or CH2—HCOH,
wherein based on the total composition, the components are present as follows:
A) 30% by weight to 98% by weight,
B) 0.01% by weight to 60% by weight,
C) 0.01% by weight to 60% by weight,
D) 0.1% by weight to 30% by weight,
E) 0.1% by weight to 30% by weight.