US 11,939,592 B2
Host bacterium specific nanoparticle
Shoichi Mitsunaka, Gifu (JP); and Hiroki Ando, Gifu (JP)
Assigned to NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, Nagoya (JP)
Appl. No. 17/275,401
Filed by NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, Nagoya (JP)
PCT Filed Dec. 5, 2019, PCT No. PCT/JP2019/047649
§ 371(c)(1), (2) Date Mar. 11, 2021,
PCT Pub. No. WO2020/137421, PCT Pub. Date Jul. 2, 2020.
Claims priority of application No. 2018-244789 (JP), filed on Dec. 27, 2018.
Prior Publication US 2022/0056474 A1, Feb. 24, 2022
Int. Cl. C12N 15/86 (2006.01); A61K 35/74 (2015.01); C12N 1/20 (2006.01); C12N 7/04 (2006.01)
CPC C12N 15/86 (2013.01) [A61K 35/74 (2013.01); C12N 1/20 (2013.01); C12N 7/045 (2013.01)] 12 Claims
 
1. A nanoparticle, consisting of a recombinant bacteriophage that includes a head and a tail, and has an ability to infect but no ability to reinfect a host bacterium, the head having stored therein a bacteriophage genome in which a part of a virion constituent gene is deleted, and
wherein the part of the virion constituent gene which is deleted is a tail gene.