US 11,939,575 B2
Modified tracrRNAs gRNAs, and uses thereof
Kevin V. Morris, Duarte, CA (US); and Tristan Scott, Duarte, CA (US)
Assigned to City of Hope, Duarte, CA (US)
Appl. No. 16/955,293
Filed by CITY OF HOPE, Duarte, CA (US)
PCT Filed Dec. 17, 2018, PCT No. PCT/US2018/066005
§ 371(c)(1), (2) Date Jun. 18, 2020,
PCT Pub. No. WO2019/126037, PCT Pub. Date Jun. 27, 2019.
Claims priority of provisional application 62/659,037, filed on Apr. 17, 2018.
Claims priority of provisional application 62/658,944, filed on Apr. 17, 2018.
Claims priority of provisional application 62/607,838, filed on Dec. 19, 2017.
Prior Publication US 2021/0017518 A1, Jan. 21, 2021
Int. Cl. C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/115 (2010.01); C12N 15/90 (2006.01); A61K 38/00 (2006.01)
CPC C12N 15/11 (2013.01) [C12N 9/22 (2013.01); C12N 15/115 (2013.01); C12N 15/907 (2013.01); A61K 38/00 (2013.01); C12N 2310/16 (2013.01); C12N 2310/20 (2017.05); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3519 (2013.01); C12N 2800/80 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A nucleic acid comprising a trans-activating crRNA (tracrRNA) sequence, wherein the tracrRNA sequence is SEQ ID NO: 171, SEQ ID NO: 203, or SEQ ID NO: 223.