US 11,939,563 B2
Continuous automated perfusion culture analysis system (CAPCAS) and applications of same
Ronald S. Reiserer, Nashville, TN (US); Gregory B. Gerken, Nashville, TN (US); David K. Schaffer, Nashville, TN (US); and John P. Wikswo, Brentwood, TN (US)
Assigned to VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed by VANDERBILT UNIVERSITY, Nashville, TN (US)
Filed on Sep. 19, 2022, as Appl. No. 17/947,302.
Application 17/947,302 is a continuation of application No. 17/578,966, filed on Jan. 19, 2022, granted, now 11,447,734.
Application 17/578,966 is a continuation in part of application No. PCT/US2021/042179, filed on Jul. 19, 2021.
Application PCT/US2021/042179 is a continuation in part of application No. PCT/US2020/040061, filed on Jun. 29, 2020.
Claims priority of provisional application 63/300,321, filed on Jan. 18, 2022.
Claims priority of provisional application 63/277,329, filed on Nov. 9, 2021.
Claims priority of provisional application 63/257,149, filed on Oct. 19, 2021.
Claims priority of provisional application 63/163,160, filed on Mar. 19, 2021.
Claims priority of provisional application 63/139,138, filed on Jan. 19, 2021.
Claims priority of provisional application 63/053,388, filed on Jul. 17, 2020.
Claims priority of provisional application 62/868,303, filed on Jun. 28, 2019.
Prior Publication US 2023/0019924 A1, Jan. 19, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12M 1/00 (2006.01); C12M 1/06 (2006.01); C12M 1/22 (2006.01); C12M 1/24 (2006.01); C12M 1/32 (2006.01); C12M 1/36 (2006.01); C12M 1/42 (2006.01); C12M 3/04 (2006.01); C12M 3/06 (2006.01)
CPC C12M 29/10 (2013.01) [C12M 23/08 (2013.01); C12M 23/10 (2013.01); C12M 23/12 (2013.01); C12M 23/16 (2013.01); C12M 23/50 (2013.01); C12M 23/58 (2013.01); C12M 27/02 (2013.01); C12M 27/12 (2013.01); C12M 35/02 (2013.01); C12M 35/04 (2013.01); C12M 41/48 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A continuous automated perfusion culture analysis system (CAPCAS), comprising:
one or more fluidic systems configured to operate large numbers of biodevices in parallel,
wherein each fluidic system comprises an array of biodevice perfusion systems and a media delivering means fluidically coupled to the array of biodevices,
wherein the media delivering means comprises a multichannel input selector valve fluidically coupled to input vials, an input pump fluidically coupled to the multichannel input selector valve, and a multichannel input director valve fluidically coupled to the input pump, configured such that the multichannel input selector valve operably selects media and/or drugs from the input vials, and the input director valve allows the input pump to deliver individually the selected media and/or drugs to each biodevice,
wherein the multichannel output collector valve has a connection to pressurized air or other gas to insert one or more bubbles between each sample.