US 11,939,433 B2
Method for preparing acylated crosslinked glycosaminoglycans
Johan Olsson, Bromma (SE); and Craig Steven Harris, Biot (FR)
Assigned to GALDERMA HOLDING S.A., Zug (CH)
Filed by Galderma Holding SA, Zug (CH)
Filed on Jun. 12, 2023, as Appl. No. 18/208,527.
Application 18/208,527 is a continuation of application No. 17/129,366, filed on Dec. 21, 2020, granted, now 11,708,461.
Application 17/129,366 is a continuation of application No. 16/066,985, granted, now 10,899,894, issued on Jan. 26, 2021, previously published as PCT/EP2016/082778, filed on Dec. 28, 2016.
Claims priority of application No. 15202944 (EP), filed on Dec. 29, 2015; application No. 16172225 (EP), filed on May 31, 2016; application No. 16172241 (EP), filed on May 31, 2016; and application No. 16172254 (EP), filed on May 31, 2016.
Prior Publication US 2023/0323041 A1, Oct. 12, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C08J 3/075 (2006.01); A61K 8/04 (2006.01); A61K 8/73 (2006.01); A61K 9/00 (2006.01); A61Q 19/00 (2006.01); C07C 209/62 (2006.01); C07C 213/00 (2006.01); C07C 269/06 (2006.01); C07F 7/08 (2006.01); C08B 37/00 (2006.01); C08B 37/08 (2006.01); C08J 3/24 (2006.01); C08J 7/14 (2006.01); C08K 5/09 (2006.01); C08L 5/00 (2006.01); C08L 5/08 (2006.01)
CPC C08J 3/075 (2013.01) [A61K 8/042 (2013.01); A61K 8/73 (2013.01); A61K 8/735 (2013.01); A61K 9/0019 (2013.01); A61Q 19/00 (2013.01); C07C 209/62 (2013.01); C07C 213/00 (2013.01); C07C 269/06 (2013.01); C07F 7/083 (2013.01); C08B 37/0063 (2013.01); C08B 37/0069 (2013.01); C08B 37/0072 (2013.01); C08J 3/24 (2013.01); C08J 7/14 (2013.01); C08K 5/09 (2013.01); C08L 5/00 (2013.01); C08L 5/08 (2013.01); C07C 2603/18 (2017.05); C08J 2305/00 (2013.01); C08J 2305/08 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A hydrogel product comprising acylated crosslinked glycosaminoglycans (GAGs), produced by a method comprising:
crosslinking (i) an at least partially deacetylated GAG comprising free amine groups and (ii) a second GAG comprising activated carboxyl groups, by forming amide bonds between 2′-amino groups on the at least partially deacetylated GAG and the activated carboxyl groups of the second GAG,
wherein the hydrogel product has residual free amine groups and a degree of acetylation of at least 95%.