US 11,939,431 B2
Temperature sensitive composition for tissue adhesion prevention and application thereof
Yu-Chia Chang, Taipei (TW); Yunn-Kuen Chang, New Taipei (TW); Wen-Yen Huang, Taipei (TW); Ging-Ho Hsiue, Hsinchu (TW); Hsieh-Chih Tsai, Taipei (TW); Shuian-Yin Lin, Zhubei (TW); Nai-Sheng Hsu, Taoyuan (TW); and Tzu-Yu Lin, Taipei (TW)
Assigned to PROVIEW-MBD BIOTECH CO., LTD., Taipei (TW)
Filed by PROVIEW-MBD BIOTECH CO., LTD., Taipei (TW)
Filed on Apr. 23, 2021, as Appl. No. 17/239,092.
Claims priority of provisional application 63/014,756, filed on Apr. 24, 2020.
Prior Publication US 2021/0330867 A1, Oct. 28, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/04 (2006.01); A61K 31/337 (2006.01); A61K 47/34 (2017.01); A61L 31/06 (2006.01); A61L 31/16 (2006.01); C08G 81/00 (2006.01); C08L 71/02 (2006.01)
CPC C08G 81/00 (2013.01) [A61K 31/337 (2013.01); A61K 47/34 (2013.01); A61L 31/041 (2013.01); A61L 31/06 (2013.01); A61L 31/16 (2013.01); C08L 71/02 (2013.01); A61L 2300/216 (2013.01); A61L 2300/416 (2013.01); A61L 2300/424 (2013.01)] 16 Claims
 
1. A composition comprising a polymer, and a carboxypolysaccharide, wherein the polymer having any one structure of the following formula (I):

OG Complex Work Unit Chemistry
or a combination thereof,
wherein:
POLY is a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide);
m and n are independently from each other 0 or 1, wherein m and n cannot be 0 simultaneously; and
AA is an amino acid residue, where its amino group directly binds to the chain-end of the POLY to form carbamate (O—C(═O)—NH) linkage.