	US 11,939,408 B2
	Hyaluronic acid derivatives
Bradley David Olsen, Arlington, MA (US); Allie Obermeyer, New York, NY (US); Sieun Kim Barnes, Melrose, MA (US); and Yun Jung Yang, Incheon (KR)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Dec. 18, 2020, as Appl. No. 17/126,700.
Claims priority of provisional application 62/951,438, filed on Dec. 20, 2019.
Prior Publication US 2021/0189018 A1, Jun. 24, 2021
Int. Cl. C08B 37/08 (2006.01); A61K 8/73 (2006.01); A61Q 19/08 (2006.01)

CPC C08B 37/0072 (2013.01) [A61K 8/735 (2013.01); A61Q 19/08 (2013.01)]

13 Claims

1. A compound of Formula (I):

or a pharmaceutically or cosmetically acceptable salt thereof, wherein:

n is an integer from 1-20,000;

each R is independently —CO₂H, or a group comprising a hydrophobic moiety;

provided that at least 1% of R groups comprise a hydrophobic moiety; wherein the group comprising a hydrophobic moiety is of Formula (II):

wherein each L is independently selected from the group consisting of:

and

m is 2-12; and

each R₂is independently a fatty acid residue of the formula —C(O)R₃, wherein each R₃is C_8-35aliphatic.