US 11,939,393 B2
Antibodies against signal-regulatory protein alpha and methods of use
Jaume Pons, San Francisco, CA (US); Bang Janet Sim, South San Francisco, CA (US); Hong Wan, Foster City, CA (US); and Tracy Chia-Chien Kuo, San Carlos, CA (US)
Assigned to ALX Oncology Inc., South San Francsico, CA (US)
Filed by ALX Oncology Inc., South San Francisco, CA (US)
Filed on Feb. 22, 2022, as Appl. No. 17/677,873.
Application 17/677,873 is a continuation of application No. 16/359,799, filed on Mar. 20, 2019, granted, now 11,292,850.
Claims priority of provisional application 62/646,210, filed on Mar. 21, 2018.
Prior Publication US 2022/0324996 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01)
CPC C07K 16/2896 (2013.01) [A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 45/06 (2013.01)] 24 Claims
 
1. An isolated antibody that binds an extracellular domain of a human SIRP-a polypeptide, wherein the antibody comprises:
(a) a heavy chain that comprises the amino acid sequence of SEQ ID NO:58, 62, or 124; and
(b) a light chain comprising a light chain variable (VL) domain that comprises the amino acid sequence of SEQ ID NO:25 or 40.