US 11,939,376 B2
T cell receptors and immune therapy using the same
Leonie Alten, Tuebingen (DE); Dominik Maurer, Moessingen (DE); Steffen Walter, Houston, TX (US); and Sebastian Bunk, Tuebingen (DE)
Assigned to Immatics Biotechnology GmbH, Tuebingen (DE)
Filed by Immatics Biotechnologies GmbH, Tuebingen (DE)
Filed on Aug. 21, 2020, as Appl. No. 17/000,143.
Application 17/000,143 is a continuation of application No. 16/402,829, filed on May 3, 2019, granted, now 10,800,845.
Application 16/402,829 is a continuation of application No. 15/677,651, filed on Aug. 15, 2017, granted, now 10,550,182, issued on Feb. 4, 2020.
Claims priority of provisional application 62/376,632, filed on Aug. 18, 2016.
Claims priority of provisional application 62/376,059, filed on Aug. 17, 2016.
Claims priority of application No. 102016115246.3 (DE), filed on Aug. 17, 2016.
Prior Publication US 2020/0385468 A1, Dec. 10, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/725 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/78 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2803 (2013.01) [A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/78 (2013.01); C07K 16/18 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/32 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01)] 20 Claims
 
1. A T cell transduced with a nucleic acid encoding an antigen recognizing construct comprising an alpha chain and a beta chain,
wherein the alpha chain comprises
SEQ ID NO: 13,
SEQ ID NO: 14,
SEQ ID NO: 15, and
the beta chain comprises
SEQ ID NO: 19,
SEQ ID NO: 20, and
SEQ ID NO: 21.