CPC C07K 14/71 (2013.01) [A61K 38/17 (2013.01); A61K 38/177 (2013.01); A61K 38/1793 (2013.01); A61K 45/06 (2013.01); A61K 47/68 (2017.08); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 14/715 (2013.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01)] | 17 Claims |
1. A method of treating graft versus host disease comprising administering a fusion protein to a subject in need thereof,
wherein the fusion protein comprises a human herpesvirus entry mediator (HVEM) protein comprising amino acids 1-202, 1-184, 39-202, or 39-184 of SEQ ID NO: 2 and an Fc protein, and
wherein the human HVEM protein comprises mutations S58R, G68T, L70W, and L90A with reference to SEQ ID NO: 2.
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