	US 11,939,365 B2
	T cell receptors recognizing mutated P53
Drew C. Deniger, Houston, TX (US); Steven A. Rosenberg, Potomac, MD (US); Anna Pasetto, Stockholm (SE); Rami Yoseph, Gaithersburg, MD (US); Winifred M. Lo, Cincinnati, OH (US); Yong-Chen Lu, Rockville, MD (US); Maria R. Parkhurst, Ellicott City, MD (US); Paul F. Robbins, Chevy Chase, MD (US); and Parisa Malekzadeh, Norfolk, VA (US)
Assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
Appl. No. 16/651,242
Filed by The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US)
PCT Filed Sep. 17, 2018, PCT No. PCT/US2018/051285 § 371(c)(1), (2) Date Mar. 26, 2020, PCT Pub. No. WO2019/067243, PCT Pub. Date Apr. 4, 2019.
Claims priority of provisional application 62/565,383, filed on Sep. 29, 2017.
Prior Publication US 2020/0277352 A1, Sep. 3, 2020
Int. Cl. C07K 14/725 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); G01N 33/574 (2006.01)

CPC C07K 14/7051 (2013.01) [A61K 35/17 (2013.01); C12N 5/0636 (2013.01); G01N 33/574 (2013.01)]

19 Claims

1. An isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53, wherein the mutated human p53 has one of the following human p53 mutations: R175H, Y220C, G245S, R248Q, or R248W, wherein the human p53 mutations are defined by reference to SEQ ID NO: 1, and wherein the TCR comprises an amino acid sequence at least 97% identical to SEQ ID NO: 23 or 24, an amino acid sequence at least 97% identical to SEQ ID NO: 25, and the amino acid sequences of:

(1) all of SEQ ID NOs: 27-32;

(2) all of SEQ ID NOs: 37-42;

(3) all of SEQ ID NOs: 47-52;

(4) all of SEQ ID NOs: 57-62;

(5) all of SEQ ID NOs: 67-72;

(6) all of SEQ ID NOs: 77-82;

(7) all of SEQ ID NOs: 87-92;

(8) all of SEQ ID NOs: 97-102;

(9) all of SEQ ID NOs: 107-112;

(10) all of SEQ ID NOs: 117-122;

(11) all of SEQ ID NOs: 127-132;

(12) all of SEQ ID NOs: 137-142;

(13) all of SEQ ID NOs: 147-152;

(14) all of SEQ ID NOs: 157-162;

(15) all of SEQ ID NOs: 167-172;

(16) all of SEQ ID NOs: 177-182;

(17) all of SEQ ID NOs: 187-192;

(18) all of SEQ ID NOs: 197-202;

(19) all of SEQ ID NOs: 207-212;

(20) all of SEQ ID NOs: 217-222;

(21) all of SEQ ID NOs: 227-232;

(22) all of SEQ ID NOs: 237-242;

(23) all of SEQ ID NOs: 247-252;

(24) all of SEQ ID NOs: 257-262;

(25) all of SEQ ID NOs: 267-272;

(26) all of SEQ ID NOs: 277-282;

(27) all of SEQ ID NOs: 287-292;

(28) all of SEQ ID NOs: 297-302;

(29) all of SEQ ID NOs: 307-312;

(30) all of SEQ ID NOs: 317-322;

(31) all of SEQ ID NOs: 327-332;

(32) all of SEQ ID NOs: 337-342;

(33) all of SEQ ID NOs: 347-352;

(34) all of SEQ ID NOs: 357-362;

(35) all of SEQ ID NOs: 367-372;

(36) all of SEQ ID NOs: 377-382;

(37) all of SEQ ID NOs: 387-392;

(38) all of SEQ ID NOs: 397-402;

(39) all of SEQ ID NOs: 407-412;

(40) all of SEQ ID NOs: 417-422;

(41) all of SEQ ID NOs: 427-432;

(42) all of SEQ ID NOs: 437-442;

(43) all of SEQ ID NOs: 447-452;

(44) all of SEQ ID NOs: 457-462;

(45) all of SEQ ID NOs: 477-482; or

(46) all of SEQ ID NOs: 487-492.