CPC C07K 14/4711 (2013.01) [A61N 5/062 (2013.01); C07K 14/4702 (2013.01); C12N 15/86 (2013.01); G01N 33/6845 (2013.01); G01N 33/6896 (2013.01); A61K 38/00 (2013.01); C07K 2319/60 (2013.01); C07K 2319/70 (2013.01); C07K 2319/735 (2013.01); C12N 2750/14143 (2013.01); G01N 2800/2835 (2013.01); G01N 2800/7047 (2013.01)] | 20 Claims |
1. A light-induced protein aggregate comprising:
(a) a fusion protein comprising an alpha-synuclein polypeptide fused to a photoactivatable polypeptide; and
(b) a proteopathic polypeptide other than alpha-synuclein that self-aggregates under pathogenic conditions,
wherein illumination of the photoactivatable polypeptide with light having a wavelength sufficient for photoactivation triggers irreversible formation of intracellular protein aggregates comprising the fusion protein and the proteopathic polypeptide.
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