US 11,939,358 B2
Compositions and methods related to protein A (SpA) variants
Olaf Schneewind, Chicago, IL (US); Alice G. Cheng, Boston, MA (US); Dominique M. Missiakas, Chicago, IL (US); and Hwan Keun Kim, Chicago, IL (US)
Assigned to The University of Chicago, Chicago, IL (US)
Filed by The University of Chicago, Chicago, IL (US)
Filed on Jun. 7, 2021, as Appl. No. 17/340,532.
Application 17/340,532 is a continuation of application No. 16/661,155, filed on Oct. 23, 2019, granted, now 11,059,866.
Application 16/661,155 is a continuation of application No. 15/702,037, filed on Sep. 12, 2017, granted, now 10,464,971.
Application 15/702,037 is a continuation of application No. 15/060,861, filed on Mar. 4, 2016, abandoned.
Application 15/060,861 is a continuation of application No. 14/466,514, filed on Aug. 22, 2014, granted, now 9,315,554.
Application 14/466,514 is a continuation of application No. 13/807,598, granted, now 8,821,894, previously published as PCT/US2011/042845, filed on Jul. 1, 2011.
Claims priority of provisional application 61/370,725, filed on Aug. 4, 2010.
Claims priority of provisional application 61/361,218, filed on Jul. 2, 2010.
Prior Publication US 2021/0290748 A1, Sep. 23, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/31 (2006.01); A61K 39/00 (2006.01); A61K 39/085 (2006.01); C07K 16/12 (2006.01)
CPC C07K 14/31 (2013.01) [A61K 39/085 (2013.01); C07K 16/1271 (2013.01); A61K 2039/57 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A polypeptide comprising a variant Staphylococcal Protein A (SpA) having an amino acid substitution at amino acid positions 9 and 10 of SEQ ID NO:2 and an amino acid sequence that is at least 70% identical to the amino acid sequence of SEQ ID NO:2.