US 11,939,345 B2
Physiologically stable fluorophore and performing fluorescence probing
Jeremiah Wallace Woodcock, Gaithersburg, MD (US); Jeffrey William Gilman, Mt. Airy, MD (US); and Douglas Matthew Fox, Reston, VA (US)
Assigned to GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE, Gaithersburg, MD (US)
Filed by Government of the United States of America, as represented by the Secretary of Commerce, Gaithersburg, MD (US)
Filed on Dec. 10, 2020, as Appl. No. 17/117,424.
Claims priority of provisional application 62/948,902, filed on Dec. 17, 2019.
Prior Publication US 2021/0179639 A1, Jun. 17, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); A61K 49/00 (2006.01); C07F 5/02 (2006.01); C08B 11/16 (2006.01); C08L 1/30 (2006.01)
CPC C07F 5/022 (2013.01) [A61K 49/0021 (2013.01); C08B 11/16 (2013.01); C08L 1/30 (2013.01)] 2 Claims
 
1. A physiologically stable fluorophore for performing fluorescence probing, the physiologically stable fluorophore comprises

OG Complex Work Unit Chemistry
wherein the physiologically stable fluorophore is stable from pH=1 to pH=10 such that the photophysics of the physiologically stable fluorophore is conserved from pH=2 to pH=10.