US 11,939,337 B2
1,5-disubstituted 1,2,3-triazoles are inhibitors of Rac/CDC42 GTPases
Cornelis P. Vlaar, San Juan, PR (US); Suranganie Dharmawardhane Flanagan, San Juan, PR (US); Eliud Hernandez-O'Farrill, San Juan, PR (US); and Linette Castillo-Pichardo, San Juan, PR (US)
Assigned to UNIVERSITY OF PUERTO RICO, San Juan, PR (US)
Filed by UNIVERSITY OF PUERTO RICO, San Juan, PR (US)
Filed on Jul. 13, 2022, as Appl. No. 17/864,198.
Application 17/864,198 is a continuation of application No. 17/220,319, filed on Apr. 1, 2021, granted, now 11,390,629.
Application 17/220,319 is a continuation of application No. 16/814,214, filed on Mar. 10, 2020, granted, now 10,995,096, issued on May 4, 2021.
Application 16/814,214 is a continuation of application No. 16/456,641, filed on Jun. 28, 2019, granted, now 10,947,247, issued on Mar. 16, 2021.
Application 16/456,641 is a continuation of application No. 15/970,268, filed on May 3, 2018, granted, now 10,392,396, issued on Aug. 27, 2019.
Application 15/970,268 is a continuation of application No. 15/499,532, filed on Apr. 27, 2017, granted, now 9,981,980, issued on May 29, 2018.
Claims priority of provisional application 62/328,282, filed on Apr. 27, 2016.
Prior Publication US 2023/0039997 A1, Feb. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 491/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 491/048 (2006.01)
CPC C07D 491/048 (2013.01) [C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01)] 20 Claims
 
1. A compound selected from the group consisting of

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.