US 11,939,336 B2
Aryl triazole cages
Amar H. Flood, Bloomington, IN (US); Yun Liu, Bloomington, IN (US); and Wei Zhao, Bloomington, IN (US)
Assigned to Indiana University Research and Technology Corporation, Bloomington, IN (US)
Appl. No. 16/965,283
Filed by INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, Indianapolis, IN (US)
PCT Filed May 22, 2019, PCT No. PCT/US2019/033631
§ 371(c)(1), (2) Date Jul. 27, 2020,
PCT Pub. No. WO2019/226839, PCT Pub. Date Nov. 28, 2019.
Claims priority of provisional application 62/675,572, filed on May 23, 2018.
Prior Publication US 2021/0363150 A1, Nov. 25, 2021
Int. Cl. C07D 487/22 (2006.01); B01D 11/04 (2006.01); B01D 15/08 (2006.01); C02F 1/26 (2023.01); C07D 471/22 (2006.01); C07D 498/22 (2006.01); C08K 5/3472 (2006.01); C09D 5/08 (2006.01)
CPC C07D 487/22 (2013.01) [B01D 11/0492 (2013.01); B01D 15/08 (2013.01); C02F 1/26 (2013.01); C07D 471/22 (2013.01); C07D 498/22 (2013.01); C09D 5/086 (2013.01); C08K 5/3472 (2013.01)] 48 Claims
 
1. An aryl-triazole bicyclic macrocycle of Formula (I):

OG Complex Work Unit Chemistry
wherein R1, R2, and R3 are independently selected from the group consisting of alkenyl, alkyl, alkoxy, alkyl-NH-alkyl, aryl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, hydrogen, iodo, —OR4, —N(R5R6), —CO2R7, —C(O)—N(R8R9), wherein R4, R5, R6, R7, R8, and R9 are each independently selected from the group consisting of alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heterocycle, haloalkyl, and hydrogen.