CPC C07D 413/06 (2013.01) | 19 Claims |
1. A process for preparing a compound of formula I:
comprising:
(i) contacting a compound of formula 1:
wherein X1 is halo;
with a metalating reagent and carbon dioxide, wherein the metalating agent is a compound of formula X-M-R, and wherein M is a metal, R is an alkyl or aryl, and X is a halide or alkali metal, to form a compound of formula 2a:
(ii) contacting a compound of formula 2a with a compound of formula:
PG-X2
wherein PG is a hydroxy protecting group and X2 is halo;
to form a compound of formula 3:
(iii) contacting a compound of formula 3 with a compound of formula 4:
to form a compound of formula 5:
(iv) contacting a compound of formula 5 with a compound of formula 6:
to form a compound of formula 7:
and
(v) deprotecting a compound of formula 7 to form a compound of formula I.
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