CPC C07D 413/04 (2013.01) | 13 Claims |
1. A method for manufacturing Compound (1):
or a pharmaceutically acceptable salt thereof, the method comprising a step of manufacturing a compound represented by Formula IXa:
or a pharmaceutically acceptable salt thereof, by treating a compound represented by Formula VIIIb:
wherein R1a represents 4-(morpholin-4-yl)piperidin-1-yl group, iodo group, or bromo group; and R2 represents an ethyl group,
with a condensing agent selected from N,N′-diisopropylcarbodiimide and diethyl chlorophosphate in a solvent selected from dichloromethane, 1,4-dioxane, 2-methyltetrahydrofuran, 2-butanone, tert-butyl methyl ether, ethyl acetate, isopropyl acetate, dimethyl sulfoxide, tetrahydrofuran, acetone, and acetonitrile.
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