US 11,939,317 B2
Amide compounds and method for making and using
Kin Tso, San Francisco, CA (US); Hui Li, Santa Clara, CA (US); Yan Chen, Foster City, CA (US); Rose Yen, San Francisco, CA (US); Vanessa Taylor, San Francisco, CA (US); Thilo Heckrodt, San Francisco, CA (US); Rajinder Singh, Belmont, CA (US); and Simon Shaw, Oakland, CA (US)
Assigned to Rigel Pharmaceuticals, Inc., South San Francisco, CA (US)
Filed by Rigel Pharmaceuticals, Inc., South San Francisco, CA (US)
Filed on Nov. 9, 2022, as Appl. No. 17/983,645.
Application 16/529,995 is a division of application No. 15/793,743, filed on Oct. 25, 2017, granted, now 10,414,753, issued on Sep. 17, 2019.
Application 17/983,645 is a continuation of application No. 17/184,199, filed on Feb. 24, 2021, granted, now 11,530,194.
Application 17/184,199 is a continuation of application No. 16/529,995, filed on Aug. 2, 2019, granted, now 10,947,216, issued on Mar. 16, 2021.
Claims priority of provisional application 62/413,299, filed on Oct. 26, 2016.
Prior Publication US 2023/0115275 A1, Apr. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01)
CPC C07D 401/14 (2013.01) [C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01)] 20 Claims
 
1. A compound, having a formula 1

OG Complex Work Unit Chemistry
or a salt thereof, wherein:
ring A is heteroaryl;
R1 is H, aliphatic, or heteroaliphatic;
R2 is H, aliphatic, heteroaliphatic, or heterocyclyl;
each of Z1, Z2, Z3, and Z4, independently is N or CR3, wherein at least one of Z1, Z2, Z3, and Z4 is N;
each R3 independently is H, aliphatic, or heteroaliphatic; and
R4 is halogen, heterocycloaliphatic, aromatic, —O-aromatic, or —NH-aromatic.