US 11,938,485 B2
Heating device for convective polymerase chain reaction
Chien-Chih Kuo, Hsinchu (TW)
Assigned to INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Hsinchu (TW)
Filed by Industrial Technology Research Institute, Hsinchu (TW)
Filed on Dec. 7, 2021, as Appl. No. 17/544,301.
Prior Publication US 2023/0173496 A1, Jun. 8, 2023
Int. Cl. C12Q 1/686 (2018.01); B01L 7/00 (2006.01); F25B 49/00 (2006.01); F25B 30/00 (2006.01)
CPC B01L 7/52 (2013.01) [B01L 7/54 (2013.01); C12Q 1/686 (2013.01); F25B 49/00 (2013.01); B01L 2200/147 (2013.01); B01L 2300/1822 (2013.01); F25B 30/00 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A heating device for a convective polymerase chain reaction, applied to form a temperature gradient and heat convection inside a container, said heating device comprising:
a heating element, configured to receive energy and further transform the energy into a first thermal energy;
a temperature sensor, configured to generate a sensing result according to the first thermal energy;
a first heat pump element, having a first surface and a second surface, configured to receive energy and further generate a first temperature difference between the first surface and the second surface;
a first heating block, contacted with the first surface of the first heat pump element and also the heating element, configured to receive the first thermal energy from the heating element and further transfer the first thermal energy to the first heat pump element, so as to have the first heat pump element to utilize the first thermal energy and the first temperature difference to generate a second thermal energy;
a second heating block, contacted with the second surface of the first heat pump element, configured to receive the second thermal energy of the first heat pump element; and
a controller, electrically connected with the temperature sensor, the heating element and the first heat pump element, configured to output the energy in correspondence with the sensing result of the temperature sensor to the heating element and the first heat pump element, so as to control the first thermal energy of the heating element and the first temperature difference of the first heat pump element;
wherein the first heating block and the second heating block are simultaneously in contact with different portions of the container longitudinally;
wherein the controller controls energy outputted to the first heat pump in accordance with the first temperature difference of the first heat pump element and a temperature-energy relationship.