US 11,938,480 B2
Microfluidic diagnostic device with a three-dimensional (3D) flow architecture
William P. King, Champaign, IL (US); Rashid Bashir, Champaign, IL (US); Mehmet Y. Aydin, Urbana, IL (US); Jacob E. Berger, Champaign, IL (US); and Enrique Valera, Champaign, IL (US)
Assigned to THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS URBANA, ILLINOIS, Urbana, IL (US)
Filed by The Board of Trustees of the University of Illinois, Urbana, IL (US)
Filed on May 11, 2021, as Appl. No. 17/316,900.
Claims priority of provisional application 63/024,692, filed on May 14, 2020.
Prior Publication US 2021/0354139 A1, Nov. 18, 2021
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502738 (2013.01) [B01L 3/502707 (2013.01); B01L 3/502753 (2013.01); B01L 2200/10 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0887 (2013.01); B01L 2400/0478 (2013.01); B01L 2400/049 (2013.01); B01L 2400/0677 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A microfluidic diagnostic device with a three-dimensional (3D) flow architecture, the microfluidic diagnostic device comprising:
a polymeric body having first and second external opposing surfaces and comprising:
first flow channels in the first external opposing surface;
second flow channels in the second external opposing surface; and
connecting flow passages extending through a thickness of the polymeric body to connect the first flow channels to the second flow channels, thereby defining a continuous 3D flow pathway in the polymeric body;
a first cover adhered to the first external opposing surface to seal the first flow channels;
a second cover adhered to the second external opposing surface to seal the second flow channels; and
one or more access ports in fluid communication with the continuous 3D flow pathway for introducing liquid reagent(s) and/or a sample into the polymeric body.