	US 11,938,456 B2
	Layered particles and processes thereof
Thomai Panagiotou, Winchester, MA (US)
Assigned to Delphi Scientific, LLC, Maynard, MA (US)
Appl. No. 16/470,136
Filed by Delphi Scientific, LLC, Maynard, MA (US)
PCT Filed Dec. 18, 2017, PCT No. PCT/US2017/066985 § 371(c)(1), (2) Date Jun. 14, 2019, PCT Pub. No. WO2018/112456, PCT Pub. Date Jun. 21, 2018.
Claims priority of provisional application 62/435,514, filed on Dec. 16, 2016.
Prior Publication US 2020/0016562 A1, Jan. 16, 2020
Int. Cl. A61K 9/50 (2006.01); B01F 23/41 (2022.01); B01F 23/45 (2022.01); B01F 23/80 (2022.01); B01J 2/00 (2006.01); B01J 13/04 (2006.01); B01F 29/00 (2022.01)

CPC B01J 13/04 (2013.01) [A61K 9/501 (2013.01); A61K 9/5036 (2013.01); A61K 9/5073 (2013.01); B01F 23/41 (2022.01); B01F 23/45 (2022.01); B01F 23/808 (2022.01); B01J 2/006 (2013.01); B01F 23/413 (2022.01); B01F 23/4146 (2022.01); B01F 29/00 (2022.01)]

19 Claims

1. A process for the preparation of layered particles comprising:

(a) forming a first liquid stream comprising:

(i) obtaining a first mixture of immiscible fluids that contains one or more core particles inside a first liquid carrier, wherein the first mixture is an emulsion;

(ii) optionally, homogenizing the first mixture; and

(iii) introducing one or more reactants into the first mixture;

(b) forming a second liquid stream comprising:

(i) introducing one or more reactants into a second liquid carrier;

(ii) mixing the one or more reactants in the second liquid carrier to form a second mixture; and

(iii) optionally, homogenizing the second mixture;

(c) continuously pumping the first liquid stream into a first port of a multi-port mixing device, wherein the first liquid stream is pumped into the mixing device at a fraction of the flow rate of the mixing device;

(d) continuously pumping the second liquid stream into a second port of the multi-port mixing device; and

(e) mixing the first liquid stream and the second liquid stream inside the mixing device for an effective period of time to form a layer on the one or more core particles, wherein the mixing is performed by the mixing device at an energy rate per kilogram of the mixture of liquid streams of from about 10⁵to about 10¹⁰W/kg.