US 11,938,261 B2
Fluid flow-through
Jon A. Dodd, Littleton, CO (US); Daniel R. Clement, Golden, CO (US); Dennis J. Hlavinka, Arvada, CO (US); Jeremy T. Parsons, Denver, CO (US); and Haralambos P. Apostolopoulos, Castle Rock, CO (US)
Assigned to Terumo BCT Biotechnologies, LLC, Lakewood, CO (US)
Filed by Terumo BCT Biotechnologies, LLC, Lakewood, CO (US)
Filed on Jul. 26, 2019, as Appl. No. 16/523,972.
Claims priority of provisional application 62/829,815, filed on Apr. 5, 2019.
Claims priority of provisional application 62/711,283, filed on Jul. 27, 2018.
Prior Publication US 2020/0030520 A1, Jan. 30, 2020
Int. Cl. B01L 3/00 (2006.01); A61L 2/00 (2006.01); A61M 1/34 (2006.01); A61M 1/36 (2006.01); A61K 41/10 (2020.01)
CPC A61M 1/3681 (2013.01) [A61L 2/0011 (2013.01); A61M 1/3455 (2013.01); A61M 1/3683 (2014.02); A61M 1/3689 (2014.02); B01L 3/502 (2013.01); A61K 41/10 (2020.01); A61M 2206/10 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0883 (2013.01); B01L 2300/12 (2013.01); B01L 2300/123 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of treating a fluid, the method comprising:
introducing a first flow of fluid into a first channel of a flow cell through an inlet port, the first channel defined by a first continuous wall having a first cross-section including at least a first dimension;
separating at a first separation zone of the flow cell the first flow of fluid into a second flow of fluid in a second channel of the flow cell and a third flow of fluid in a third channel of the flow cell, the second channel extending from the first channel at a right angle, the second channel defined by a second continuous wall and the third channel defined by a third continuous wall that is different from the second continuous wall, the first continuous wall splitting into the second continuous wall and the third continuous wall in the first separation zone;
reorienting at least the second flow of fluid in the second channel in a first reorienting zone including areas of both the second channel and the third channel, the second channel changes direction at least once to reorientate the second flow of fluid;
recombining the second flow of fluid with the third flow of fluid in a first recombining zone where the second channel and the third channel merge from different directions into a fourth channel of the flow cell defined by a fourth continuous wall to form a fourth flow of fluid;
separating at a second separation zone of the flow cell the fourth flow of fluid into a fifth flow of fluid in a fifth channel of the flow cell and a sixth flow of fluid in a sixth channel of the flow cell, the fifth channel extending from the fourth channel at a right angle relative to the fourth channel, the fifth channel defined by a fifth continuous wall and the sixth channel defined by a sixth continuous wall that is different from the fifth continuous wall, the fourth continuous wall splitting into the fifth continuous wall and the sixth continuous wall in the second separation zone;
reorienting at least the fifth flow of fluid in the fifth channel in a second reorientating zone including areas of both the fifth channel and the sixth channel, the fifth channel changes direction at least once to reorientate the fifth flow of fluid;
recombining the fifth flow of fluid with the sixth flow of fluid in a second recombining zone where the fifth channel and the sixth channel merge from different directions into a seventh channel of the flow cell defined by a seventh continuous wall to form a seventh flow of fluid; and
treating with electromagnetic energy one or more of the first flow of fluid, the second flow of fluid, the third flow of fluid, the fourth flow of fluid, the fifth flow of fluid, the sixth flow of fluid, or seventh flow of fluid;
wherein the first continuous wall splits into the second continuous wall and the third continuous wall in the first separation zone, and the second continuous wall and the third continuous wall merge into the fourth continuous wall in the first recombining zone;
wherein the fourth continuous wall splits into the fifth continuous wall and the sixth continuous wall in the second separation zone, and the fifth continuous wall and the sixth continuous wall merge into the seventh continuous wall in the second recombining zone;
wherein the first channel, the second channel, the third channel, the fourth channel, the fifth channel, the sixth channel, and the seventh channel are together configured to direct the fluid through all three dimensions of a three-dimensional space; and
wherein at least one of the first separation zone, the second separation zone, the first reorienting zone, the second reorienting zone, the first recombining zone, and the second recombining zone are substantially transmissive to a form of electromagnetic energy.