US 11,938,253 B2
Gas exchange composite membranes and methods of use thereof
Shuvo Roy, San Ramon, CA (US); Torin Yeager, San Francisco, CA (US); Emily Abada, San Francisco, CA (US); and Ajay S. Dharia, San Bruno, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on May 7, 2020, as Appl. No. 16/868,836.
Application 16/868,836 is a continuation of application No. 15/527,590, granted, now 10,695,480, previously published as PCT/US2015/061422, filed on Nov. 18, 2015.
Claims priority of provisional application 62/081,896, filed on Nov. 19, 2014.
Prior Publication US 2020/0397967 A1, Dec. 24, 2020
Int. Cl. A61M 1/16 (2006.01); A61M 1/26 (2006.01); B01D 53/22 (2006.01); B01D 69/02 (2006.01); B01D 69/12 (2006.01); B01D 71/70 (2006.01)
CPC A61M 1/1698 (2013.01) [A61M 1/267 (2014.02); B01D 53/228 (2013.01); B01D 69/02 (2013.01); B01D 69/12 (2013.01); B01D 71/70 (2013.01); A61M 2202/0478 (2013.01); A61M 2209/088 (2013.01); B01D 2257/104 (2013.01); B01D 2325/02 (2013.01); B01D 2325/04 (2013.01); B01D 2325/20 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A method of exchanging gas with blood from a circulatory system of a subject comprising a first dissolved gaseous compound, the method comprising:
A) providing a blood oxygenating device comprising:
a) gas exchange composite membrane comprising:
i) a non-porous, gas-permeable, polymeric membrane defining a first surface and a second surface opposite the first surface; and
ii) a non-compliant, microporous membrane defining a third surface and a fourth surface opposite the third surface,
wherein the non-compliant, microporous membrane comprises one or more gas diffusion windows, each comprising a network of struts defining walls of a plurality of micropores, each micropore extending from the third surface to the fourth surface,
wherein the third surface is attached to the second surface;
b) a non-circuitous blood channel located adjacent to the first surface of the non-porous, gas-permeable, polymeric membrane,
wherein the blood channel defines a first end and a second end opposite the first end,
wherein the blood channel is a part of an extracorporeal blood circuit;
c) a gas channel located adjacent to the fourth surface of the non-compliant, microporous membrane, wherein the gas channel is configured to pass a flow of gas,
wherein the first surface provides an antithrombotic surface for gas exchange over the one or more gas diffusion windows between blood flowing along the first surface and a gas at the second surface;
B) pumping the blood from the circulatory system of the subject through the non-circuitous blood channel to generate a circulating flow of the blood; and
C) flowing a gas comprising a second gaseous compound through the gas channel,
thereby exchanging gaseous compounds between the circulating flow of the blood and the gas.