US 11,938,248 B2
Electrospinning with sacrificial template for patterning fibrous constructs
Eric M. Jeffries, Pittsburgh, PA (US); Yadong Wang, Allison Park, PA (US); and James H. Clampffer, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh - Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Aug. 24, 2020, as Appl. No. 17/001,177.
Application 17/001,177 is a division of application No. 15/123,581, granted, now 10,780,198, previously published as PCT/US2015/019146, filed on Mar. 6, 2015.
Claims priority of provisional application 61/948,906, filed on Mar. 6, 2014.
Prior Publication US 2020/0384159 A1, Dec. 10, 2020
Int. Cl. A61L 27/56 (2006.01); A61F 2/06 (2013.01); A61F 2/07 (2013.01); A61L 27/18 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 33/06 (2006.01); B33Y 10/00 (2015.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01); D01D 5/00 (2006.01); D01F 6/62 (2006.01); D01F 6/74 (2006.01)
CPC A61L 27/507 (2013.01) [A61F 2/06 (2013.01); A61F 2/07 (2013.01); A61L 27/18 (2013.01); A61L 27/3679 (2013.01); A61L 27/3808 (2013.01); A61L 27/3886 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 33/068 (2013.01); B33Y 10/00 (2014.12); B33Y 70/00 (2014.12); B33Y 80/00 (2014.12); D01D 5/0007 (2013.01); D01F 6/62 (2013.01); D01F 6/74 (2013.01); A61F 2210/0004 (2013.01); A61F 2210/0076 (2013.01); A61F 2230/0026 (2013.01); A61F 2240/001 (2013.01); A61F 2240/004 (2013.01); A61F 2240/005 (2013.01); A61F 2250/0067 (2013.01); A61L 27/3804 (2013.01); A61L 2300/42 (2013.01); A61L 2300/606 (2013.01); D10B 2509/06 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for fabricating a fibrous construct, comprising:
electrospinning a first layer of fibrous material;
printing a micropatterned sacrificial template comprising a user-defined pattern for producing at least one channel or microstructure onto the first layer of fibrous material, wherein the printing and the electrospinning are performed on the same platform;
electrospinning a second layer of fibrous material onto the micropatterned sacrificial template, thereby encapsulating the template and generating a construct comprising the first layer and the second layer of electrospun material and the micropatterned sacrificial template;
removing the sacrificial template; and
generating the fibrous construct patterned with the at least one channel or microstructure produced by removing the sacrificial template, wherein the at least one channel or microstructure extends through the fibrous construct.