US 11,938,245 B2
Cartilage-derived implants and methods of making and using same
Michael A. Nasert, Hazlet, NJ (US); Florence Stoffel, Whitehouse Station, NJ (US); Paul R. Williams, Boise, ID (US); and Alex Callahan, Eatontown, NJ (US)
Assigned to Musculoskeletal Transplant Foundation, Edison, NJ (US)
Filed by Musculoskeletal Transplant Foundation, Edison, NJ (US)
Filed on Mar. 31, 2021, as Appl. No. 17/218,410.
Application 17/218,410 is a division of application No. 15/236,975, filed on Aug. 15, 2016, granted, now 11,052,175.
Claims priority of provisional application 62/207,146, filed on Aug. 19, 2015.
Prior Publication US 2021/0213166 A1, Jul. 15, 2021
Int. Cl. A61L 27/36 (2006.01); B29B 13/04 (2006.01); B29C 65/56 (2006.01); B29L 31/00 (2006.01)
CPC A61L 27/3612 (2013.01) [A61L 27/3654 (2013.01); B29B 13/04 (2013.01); B29C 65/565 (2013.01); A61L 2430/06 (2013.01); B29K 2995/0056 (2013.01); B29L 2031/7532 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for producing cartilage fibers comprising:
grating recovered cartilage using a grater having a plurality of cutting features, each of which has an opening and a raised cutting surface with a cutting edge which was formed by a die stamping technique, to produce a plurality of cartilage fibers each having three or more laterally-oriented striations and which enable the cartilage fibers to entangle with one another to a greater degree than cartilage fibers without such striations and form a cohesive mass having a shape and which retains said shape until reshaped and, when implanted in a shaped cavity of a cartilage defect, is capable of conforming to and completely filling the shaped cavity and resists swelling, deformation, and migration from the shaped cavity upon hydration with a fluid to a greater degree than cartilage fibers without such striations; and
optionally, storing the plurality of cartilage fibers in storage media.