US 11,938,193 B2
Compositions comprising chemerin and methods of use thereof
Russell Pachynski, St. Louis, MO (US); Holbrook Kohrt, Palo Alto, CA (US); Jason Yonehiro, Palo Alto, CA (US); and Brian Zabel, Palo Alto, CA (US)
Assigned to Washington University, St. Louis, MO (US)
Appl. No. 16/068,890
Filed by Washington University, St. Louis, MO (US)
PCT Filed Jan. 9, 2017, PCT No. PCT/US2017/012725
§ 371(c)(1), (2) Date Jul. 9, 2018,
PCT Pub. No. WO2017/120589, PCT Pub. Date Jul. 13, 2017.
Claims priority of provisional application 62/276,595, filed on Jan. 8, 2016.
Prior Publication US 2019/0008982 A1, Jan. 10, 2019
Int. Cl. A61K 47/68 (2017.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 14/52 (2006.01); A61K 38/00 (2006.01)
CPC A61K 47/6813 (2017.08) [A61K 45/06 (2013.01); A61K 47/6849 (2017.08); A61K 47/6869 (2017.08); A61P 35/00 (2018.01); C07K 14/4702 (2013.01); C07K 14/52 (2013.01); C07K 14/521 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01)] 17 Claims
 
1. A polynucleotide sequence encoding a polypeptide, the polypeptide comprising chemerin linked via a linker to a targeting moiety, wherein the linker comprises SEQ ID NO: 8 and wherein the targeting moiety is capable of directing the chemerin to a target site on a cell.