	US 11,938,186 B2
	Thermosensitive hydrogel for cancer therapeutics and methods of preparation thereof
Baseeruddin Alvi Syed, Sangareddy (IN); Rajalakshmi P. S., Sangareddy (IN); and Aravind Kumar Rengan, Sangareddy (IN)
Assigned to Indian Institute of Technology Hyderabad, Telangana (IN)
Filed by INDIAN INSTITUTE OF TECHNOLOGY HYDERABAD, Telangana (IN)
Filed on May 20, 2021, as Appl. No. 17/325,290.
Claims priority of application No. 202041021283 (IN), filed on May 20, 2020.
Prior Publication US 2021/0393780 A1, Dec. 23, 2021
Int. Cl. A61K 47/32 (2006.01); A61K 9/06 (2006.01); A61K 9/127 (2006.01); A61K 31/704 (2006.01); A61K 33/242 (2019.01); A61K 41/00 (2020.01); A61K 47/34 (2017.01); A61K 47/42 (2017.01); A61P 35/00 (2006.01)

CPC A61K 41/0028 (2013.01) [A61K 9/06 (2013.01); A61K 9/1271 (2013.01); A61K 31/704 (2013.01); A61K 33/242 (2019.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/42 (2013.01); A61P 35/00 (2018.01)]

20 Claims

1. A thermosensitive hydrogel comprising polyvinyl alcohol, poloxamer 407 and bovine serum albumin, and a pharmaceutically acceptable carrier that comprises sterile aqueous media, solid diluents, fillers, excipients, and plural non-toxic organic solvents, wherein the polyvinyl alcohol is a water-soluble polymer and the poloxamer is a tri-block polymer that includes a central hydrophobic block of polypropylene glycol (PPG) flanked by two hydrophilic blocks of polyethylene glycol (PEG).