US 11,938,181 B2
Identifying patient populations vulnerable to viral infection and methods of inducing heterologous immunity in same
Colin Pawlowski, Boston, MA (US); Venkataramanan Soundararajan, Andover, MA (US); Arjun Puranik, San Jose, CA (US); and Murali Aravamudan, Andover, MA (US)
Assigned to nference, Inc., Cambridge, MA (US)
Filed by nference, Inc., Cambridge, MA (US)
Filed on Jul. 9, 2021, as Appl. No. 17/371,555.
Claims priority of provisional application 63/055,751, filed on Jul. 23, 2020.
Claims priority of provisional application 63/050,349, filed on Jul. 10, 2020.
Prior Publication US 2022/0016233 A1, Jan. 20, 2022
Int. Cl. A61K 39/215 (2006.01); A61K 39/00 (2006.01); A61K 39/09 (2006.01); A61K 39/116 (2006.01); A61K 39/145 (2006.01); A61K 39/25 (2006.01); A61K 39/29 (2006.01); A61K 39/295 (2006.01); A61P 31/14 (2006.01); A61P 37/04 (2006.01)
CPC A61K 39/215 (2013.01) [A61K 39/092 (2013.01); A61K 39/116 (2013.01); A61K 39/145 (2013.01); A61K 39/25 (2013.01); A61K 39/29 (2013.01); A61K 39/292 (2013.01); A61K 39/295 (2013.01); A61P 31/14 (2018.01); A61P 37/04 (2018.01); A61K 2039/55 (2013.01)] 16 Claims
 
1. A method for reducing the risk of a subject acquiring or fully presenting a disease case by SARS-CoV-2 infection, comprising:
determining a plurality of demographic covariates of the subject, wherein
determining the plurality of demographic covariates comprises:
determining a propensity score for the subject; and
generating at least a negative cohort as a function of the propensity score;
identifying one or more vaccines not administered to the subject within the past 1 year, the one or more vaccines not having been administered to the subject within the past 1 year selected from a group comprising a haemophilus influenzae type B (Hib) vaccine, an influenza vaccine, a diphtheria-pertussis-tetanus vaccine, and a measles-mumps-rubella vaccine using a logistic regression model as a function of the plurality of demographic covariates of the subject and the propensity score; and
administering to the subject at least one of the one or more vaccines identified as not having been administered to the subject within the past 1 year.