US 11,938,136 B2
Compositions for treating spinal muscular atrophy
Jochem Alsenz, Basel (CH); Olaf Grassmann, Basel (CH); Peter Kuehl, Basel (CH); Friedrich Metzger, Basel (CH); Kathleen Dorothy Mccarthy, Basel (CH); Eduardo Paulo Morawski Vianna, Basel (CH); and Marvin Lloyd Woodhouse, Basel (CH)
Assigned to Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed by Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed on Nov. 15, 2019, as Appl. No. 16/685,431.
Application 16/685,431 is a continuation of application No. 15/955,337, filed on Apr. 17, 2018, abandoned.
Application 15/955,337 is a continuation of application No. PCT/EP2016/076905, filed on Nov. 8, 2016.
Claims priority of application No. 15194297 (EP), filed on Nov. 12, 2015.
Prior Publication US 2020/0323856 A1, Oct. 15, 2020
Int. Cl. A61K 31/519 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/14 (2006.01); A61K 31/5025 (2006.01); A61K 31/575 (2006.01); A61K 45/06 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/0053 (2013.01); A61K 9/0095 (2013.01); A61K 9/08 (2013.01); A61K 9/14 (2013.01); A61K 9/145 (2013.01); A61K 31/5025 (2013.01); A61K 31/575 (2013.01); A61K 45/06 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 2300/00 (2013.01)] 47 Claims
 
1. A dry granulated powder blend for an oral solution, said dry granulated powder blend comprising
7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one or a pharmaceutically acceptable salt thereof;
a stabilizer comprising disodium ethylenediaminetetraacetate;
an antioxidant comprising ascorbic acid; and
an acidifier comprising tartaric acid.