US 11,938,115 B2
Benzoselenophene-based compound, pharmaceutical composition containing same, and antibody-drug conjugate
Dongyeol Lim, Seoul (KR); Min Cheol Kim, Seoul (KR); Amol Mhetre, Seoul (KR); and Do-Hyun Nam, Seoul (KR)
Assigned to AIMED BIO INC., Seoul (KR)
Filed by AIMED BIO INC., Seoul (KR)
Filed on Jul. 29, 2022, as Appl. No. 17/815,958.
Application 17/815,958 is a continuation of application No. PCT/KR2021/001082, filed on Jan. 27, 2021.
Claims priority of application No. 10-2020-0011222 (KR), filed on Jan. 30, 2020.
Prior Publication US 2022/0380360 A1, Dec. 1, 2022
Int. Cl. A61K 31/404 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07D 421/06 (2006.01)
CPC A61K 31/404 (2013.01) [A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61K 47/6855 (2017.08); A61K 47/6857 (2017.08); A61K 47/6859 (2017.08); A61K 47/6861 (2017.08); A61K 47/6863 (2017.08); A61K 47/6865 (2017.08); A61K 47/6867 (2017.08); A61K 47/6869 (2017.08); A61P 35/00 (2018.01); C07D 421/06 (2013.01)] 20 Claims
 
1. A benzoselenophene-based compound, represented by the following Chemical Formula 1:

OG Complex Work Unit Chemistry
in the above Chemical Formula 1,
R1 is a substituted or unsubstituted C3-10 heterocycloalkyl group including at least one nitrogen atom or a substituted or unsubstituted C3-10 heteroaryl group including at least one nitrogen atom,
each of R2 and R3 is independently hydrogen, fluorine, chlorine, bromine, iodine, or a substituted or unsubstituted C1-5 alkyl group,
each of R4 and R5 is independently hydrogen, or a substituted or unsubstituted C1-5 alkyl group,
the heterocycloalkyl group and the heteroaryl group further include at least one hetero atom selected from O and S or not,
X is halogen, and
if one or more of R1, R2, R3, R4 or R5 is substituted, the substituent is one or more members selected from the group consisting of an acyl group, an amino group, an acylamino group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkoxycarbonyloxy group, an alkoxycarbonyl group, a carboxy group, a carboxylate group, an aminocarbonyl group, a mono- and dialkylaminocarbonyl groups, a cyano group, an azido group, a halogen group, a hydroxyl group, a nitro group, a trifluoromethyl group, a thiol group, an alkylthiol group, an arylthiol group, an alkylthiocarbonyl group, a thiocarboxylate group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, a lower alkoxy group, an aryloxy group, an aryloxycarbonyloxy group, a benzyloxy group, a benzyl group, a sulfinyl group, an alkylsulfinyl group, a sulfonyl group, a sulfate group, a sulfonate group, a sulfonamide group, a phosphate group, a phosphonate group, a phosphinato group, an oxo group, a guanidine group, an imino group and a formyl group.