US 11,938,111 B2
Pharmaceutical compositions of dimethyl fumarate
Sami Karaborni, Cupertino, CA (US); Wei Chen, Cupertino, CA (US); and Suresh Kumar Manthati, Sunnyvale, CA (US)
Assigned to ARBOR PHARMACEUTICALS, LLC, Atlanta, GA (US)
Filed by ARBOR PHARMACEUTICALS, LLC, Atlanta, GA (US)
Filed on Dec. 15, 2021, as Appl. No. 17/551,550.
Application 17/551,550 is a division of application No. 16/749,427, filed on Jan. 22, 2020, granted, now 11,229,621.
Application 16/206,521 is a division of application No. 14/223,026, filed on Mar. 24, 2014, granted, now 10,179,118, issued on Jan. 15, 2019.
Application 16/749,427 is a continuation of application No. 16/206,521, filed on Nov. 30, 2018, granted, now 10,576,055, issued on Mar. 3, 2020.
Claims priority of provisional application 61/805,869, filed on Mar. 27, 2013.
Claims priority of provisional application 61/805,516, filed on Mar. 26, 2013.
Claims priority of provisional application 61/805,137, filed on Mar. 25, 2013.
Claims priority of provisional application 61/804,725, filed on Mar. 24, 2013.
Prior Publication US 2022/0105067 A1, Apr. 7, 2022
Int. Cl. A61K 31/336 (2006.01); A61J 1/03 (2023.01); A61K 31/194 (2006.01); A61K 31/215 (2006.01); A61K 31/225 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/403 (2006.01); A61K 9/48 (2006.01)
CPC A61K 31/336 (2013.01) [A61J 1/035 (2013.01); A61K 31/194 (2013.01); A61K 31/215 (2013.01); A61K 31/225 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/403 (2013.01); A61K 9/4825 (2013.01)] 7 Claims
 
1. A dosage form for treating multiple sclerosis, comprising:
(a) a therapeutically effective amount of dimethyl fumarate in solid form;
(b) one or more compounds of Formula (IV):

OG Complex Work Unit Chemistry
isomers thereof and salts of any of the foregoing, wherein:
each of R11 and R12 is independently chosen from hydrogen and methyl; and
wherein the one or more compounds of Formula (IV) are impurities and are present in a combined total amount of about 0.001% to 2% by weight based on total weight of the dimethyl fumarate; and
(c) a pharmaceutically acceptable vehicle.