US 11,938,105 B1
Methods and compositions for the treatment of cancer cachexia
Ching-Shih Chen, Columbus, OH (US); Christopher C. Coss, Columbus, OH (US); Samuel Kulp, Columbus, OH (US); Yu-Chou Tseng, Columbus, OH (US); and Tanios Bekaii-Saab, Columbus, OH (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US)
Filed by Ohio State Innovation Foundation, Columbus, OH (US)
Filed on Dec. 19, 2022, as Appl. No. 18/067,924.
Application 18/067,924 is a continuation of application No. 16/646,424, granted, now 11,529,323, previously published as PCT/US2018/050928, filed on Sep. 13, 2018.
Claims priority of provisional application 62/558,228, filed on Sep. 13, 2017.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/167 (2006.01); A61K 45/06 (2006.01); A61P 21/06 (2006.01)
CPC A61K 31/167 (2013.01) [A61K 45/06 (2013.01); A61P 21/06 (2018.01)] 3 Claims
OG exemplary drawing
 
1. A method for treating cancer cachexia in a subject, comprising administering to the subject a therapeutically effective amount of
AR-42, having the following chemical structure:

OG Complex Work Unit Chemistry
and
a class I/IIB HDAC inhibitor and an androgen receptor modulator.