US 11,938,102 B2
S-enantiomerically enriched compositions of beta blockers for treating amyotrophic lateral sclerosis
Andrew J. S. Coats, St. Kilda (AU); Stefan Anker, Berlin (DE); and Jochen Springer, Falkensee (DE)
Assigned to ACTIMED THERAPEUTICS LIMITED, Ascot (GB)
Filed by ACTIMED THERAPEUTICS LIMITED, Ascot (GB)
Filed on Apr. 15, 2021, as Appl. No. 17/231,789.
Application 17/231,789 is a continuation of application No. 16/657,018, filed on Oct. 18, 2019, granted, now 11,007,158.
Application 16/657,018 is a continuation of application No. 14/776,037, granted, now 10,449,166, issued on Oct. 22, 2019, previously published as PCT/AU2014/000274, filed on Mar. 14, 2014.
Claims priority of provisional application 61/786,235, filed on Mar. 14, 2013.
Prior Publication US 2021/0330615 A1, Oct. 28, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/138 (2006.01)
CPC A61K 31/138 (2013.01) 13 Claims
 
1. A method of increasing locomotive activity in an individual having amyotrophic lateral sclerosis, comprising administering to the individual an effective amount of a composition comprising a beta blocker which is oxprenolol or a pharmaceutically acceptable salt thereof, wherein the composition is enantiomerically enriched for the S-enantiomer of the beta-blocker, wherein the composition comprises an enantiomeric excess of at least about 50% of S-oxprenolol.