CPC C07K 16/18 (2013.01) [A61K 35/17 (2013.01); C07K 14/47 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12Q 1/6876 (2013.01); G01N 33/5023 (2013.01); G01N 33/505 (2013.01); G01N 33/6854 (2013.01); G01N 33/6872 (2013.01); G01N 33/9493 (2013.01); A61K 38/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/17 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01)] | 5 Claims |
1. A method for screening an agent for Lrig (leucine-rich repeats and immunoglobulin-like domain) up-regulating activity comprising:
(a) contacting the agent with a regulatory T cell expressing Lrig protein;
(b) measuring an expression level of the Lrig expressed by the regulatory T cell; and
(c) determining that the agent has Lrig up-regulating activity when the expression level of Lrig of the regulatory T cell is up-regulated.
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