CPC C07D 495/04 (2013.01) [A61P 29/00 (2018.01)] | 16 Claims |
1. A method of inhibiting cyclooxygenase-2 (COX-2) in a patient comprising administering to a patient in need thereof a compound having the formula I:
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is selected from the group consisting of —CH2-phenyl and —NH-(C═O)-phenyl,
wherein the phenyl in either of the —CH2-phenyl and —NH-(C═O)-phenyl is substituted with one substituent selected from the group consisting of a halogen, methoxy, and CF3.
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