US 11,932,601 B2
Immunoregulatory agents
Hilary Plake Beck, Emerald Hills, CA (US); Juan Carlos Jaen, Burlingame, CA (US); Maksim Osipov, Belmont, CA (US); Jay Patrick Powers, Pacifica, CA (US); Maureen Kay Reilly, Belmont, CA (US); Hunter Paul Shunatona, San Francisco, CA (US); James Ross Walker, Menlo Park, CA (US); Mikhail Zibinsky, Lodi, CA (US); James Aaron Balog, Lambertville, NJ (US); David K. Williams, Delran, NJ (US); and Weiwei Guo, Lawrenceville, NJ (US)
Assigned to Flexus Biosciences, Inc., Princeton, NJ (US)
Filed by FLEXUS BIOSCIENCES, INC., Princeton, NJ (US)
Filed on Dec. 16, 2021, as Appl. No. 17/552,517.
Application 17/552,517 is a continuation of application No. 15/524,113, granted, now 11,242,319, previously published as PCT/US2015/059271, filed on Nov. 5, 2015.
Claims priority of provisional application 62/075,663, filed on Nov. 5, 2014.
Prior Publication US 2022/0274926 A1, Sep. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 213/75 (2006.01); A61K 31/167 (2006.01); A61K 31/195 (2006.01); A61K 31/277 (2006.01); A61K 31/343 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/505 (2006.01); A61K 31/5375 (2006.01); A61K 39/39 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 37/06 (2006.01); C07C 233/11 (2006.01); C07C 233/15 (2006.01); C07C 233/28 (2006.01); C07C 233/29 (2006.01); C07C 233/66 (2006.01); C07C 235/26 (2006.01); C07C 235/36 (2006.01); C07C 235/38 (2006.01); C07C 237/20 (2006.01); C07C 237/22 (2006.01); C07C 255/57 (2006.01); C07C 255/60 (2006.01); C07C 317/40 (2006.01); C07C 317/44 (2006.01); C07C 321/28 (2006.01); C07C 323/41 (2006.01); C07D 207/27 (2006.01); C07D 213/56 (2006.01); C07D 231/12 (2006.01); C07D 239/42 (2006.01); C07D 277/30 (2006.01); C07D 295/15 (2006.01); C07D 295/155 (2006.01); C07D 309/04 (2006.01); C07D 309/06 (2006.01); C07D 317/46 (2006.01); C07D 317/66 (2006.01); A61K 39/00 (2006.01)
CPC C07D 213/75 (2013.01) [A61K 31/167 (2013.01); A61K 31/195 (2013.01); A61K 31/277 (2013.01); A61K 31/343 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/505 (2013.01); A61K 31/5375 (2013.01); A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 37/06 (2018.01); C07C 233/11 (2013.01); C07C 233/15 (2013.01); C07C 233/28 (2013.01); C07C 233/29 (2013.01); C07C 233/66 (2013.01); C07C 235/26 (2013.01); C07C 235/36 (2013.01); C07C 235/38 (2013.01); C07C 237/20 (2013.01); C07C 237/22 (2013.01); C07C 255/57 (2013.01); C07C 255/60 (2013.01); C07C 317/40 (2013.01); C07C 317/44 (2013.01); C07C 321/28 (2013.01); C07C 323/41 (2013.01); C07D 207/27 (2013.01); C07D 213/56 (2013.01); C07D 231/12 (2013.01); C07D 239/42 (2013.01); C07D 277/30 (2013.01); C07D 295/15 (2013.01); C07D 295/155 (2013.01); C07D 309/04 (2013.01); C07D 309/06 (2013.01); C07D 317/46 (2013.01); C07D 317/66 (2013.01); A61K 2039/55511 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); Y02A 50/30 (2018.01)] 17 Claims
OG exemplary drawing
 
1. A compound that is:
cis-N-(5-Chloropyridin-2-yl)-2-((1,4)-4-phenylcyclohexyl) acetamide;
trans-N-(5-Chloropyridin-2-yl)-241,4)-4-phenylcyclohexyl)acetamide;
cis-N-(4-(2-Hydroxypropan-2-yl)phenyl)-2-((1,4)-4-phenylcyclohexyl)acetamide;
trans-N-(4-(2-Hydroxypropan-2-yl)phenyl)-2-((1,4)-4-phenylcyclohexyl)acetamide;
cis-N-(4-(Hydroxymethyl)phenyl)-2-((1,4)-4-phenylcyclohexyl)acetamide;
trans-N-(4-(Hydroxymethyl)phenyl)-2-((1,4)-4-phenylcyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-phenylcyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-phenylcyclohexyl)acetamide;
cis-N-Phenyl-2-(4-phenylcyclohexyl)acetamide;
cis-N-(4-Methoxyphenyl)-2-(4-phenylcyclohexyl)acetamide;
cis-N-(4-Methoxy-3-fluorophenyl)-2-(4-phenylcyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-phenylcyclohexyl)acetamide;
cis-N-(4-Methylphenyl)-2-(4-phenylcyclohexyl)acetamide;
N-(4-Cyanophenyl)-2-(4-phenylcyclohexyl)acetamide;
N-(4-Trifluoromethoxyphenyl)-2-(4-phenylcyclohexyl)acetamide,
N-(4-Bromophenyl)-2-(4-phenylcyclohexyl)acetamide,
cis-N-(4-Tertbutylphenyl)-2-(4-phenylcyclohexyl)acetamide,
cis-N-(3-Fluoro-4-chlorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(3-Fluoro-4-chlorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-([1, 1-Biphenyl]-4-yl)-2-(4-phenylcyclohexyl)acetamide,
trans-N-([1, 1’-Biphenyl]-4-yl)-2-(4-phenylcyclohexyl)acetamide,
cis-N-(4-Chloro-2-fluorophenyl)-2-(4-phenylcyclohexyl)acetamide,
trans-N-(4-Chloro-2-fluorophenyl)-2-(4-phenyl cyclohexyl)acetamide,
2-(-4-(4-Methoxyphenyl)cyclohexyl)-N-(4-(methylthio)phenyl)acetamide,
trans-2-(4-(4-Methoxyphenyl)cyclohexyl)-N-(4-(methylthio)phenyl)acetamide,
cis-2-(4-(4-Methoxyphenyl)cyclohexyl)-N-(4-(methyl sulfonyl)phenyl)acetamide,
cis-N-(3-Cyanophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(3-Cyanophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyclopropylphenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Cyclopropylphenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(3-Fluoro-4-chlorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Tertbutylphenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(3,4-Difluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(3,4-Difluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-241,4)-4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-241,4)-4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-([1, 1′-Biphenyl]-4-yl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chloro-2-fluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Chloro-2-fluorophenyl)-2-(4-(4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2-(4-(4-cyanophenyl)cyclohexyl)acetamide,
cis-N-(4-Fluorophenyl)-2-(4-(4-cyanophenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2-(4-(4-fluorophenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(4-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-fluorophenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(4-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(4-methylphenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(4-methylphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-methylphenyl)cyclohexyl)acetamide;
N-(4-Chlorophenyl)-2-(4-(4-morpholinophenyl)cyclohexyl)acetamide;
N-(4-Chlorophenyl)-2-(4-(4-morpholinophenyl)cyclohexyl)acetamide;
N-(4-Fluorophenyl)-2-(4-(4-morpholinophenyl)cyclohexyl)acetamide;
2-(4-(4-(Dimethylamino)phenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide;
2-(4-(4-(Dimethylamino)phenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(4-isopropoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-ethoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(4-ethoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(4-(methylsulfonyl)phenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(4-(methylsulfonyl)phenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(4-(methylsulfonyl)phenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(4-(methylsulfonyl)phenyl)cyclohexyl)acetamide;
cis-4-(-4-(2-((4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzoic acid;
trans-4-(4-(2-((4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzoic acid;
cis-4-(4-(2-((4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide;
trans-4-(4-(2-(4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide;
cis-4-(4-(2-((4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
trans-4-(4-(2-(4-Chlorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
cis-4-(4-(2-((4-Fluorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
trans-4-(4-(2-((4-Fluorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
cis-4-(4-(2-((4-Fluorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
trans-4-(4-(2-((4-Fluorophenyl)amino)-2-oxoethyl)cyclohexyl)benzamide,
cis-N-(4-Cyanophenyl)-2-41,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
trans-N-(4-Cyanophenyl)-2-((1,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
cis-N-(4-Fluorophenyl)-2-41,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
trans-N-(4-Fluorophenyl)-2-41,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
cis-N-(4-Chlorophenyl)-2-41,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
trans-N-(4-Chlorophenyl)-2-41,4)-4-(4-(trifluoromethoxy)phenyl)cyclohexyl)-acetamide,
cis-N-(4-Chlorophenyl)-2-(4-(4-ethoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Chlorophenyl)-2-(4-(4-ethoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide,
trans-N-(4-Chlorophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide,
trans-N-(4-Cyanophenyl)-2-(4-(3-cyanophenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide,
trans-N-(4-Chlorophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide,
cis-N-(4-Fluorophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide,
trans-N-(4-Fluorophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide;
trans-N-(4-Cyanophenyl)-2-(4-(3-((2-oxopyrrolidin-1-yl)methyl)phenyl)cyclohexyl) acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(3-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(3-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(3-fluorophenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(3-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Cyanophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Cyanophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(3-carboxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Cyanophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
trans-N-(4-Cyanophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(3-carboxamidophenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(2-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(2-fluorophenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(2-fluorophenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Chloro-3-fluorophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Chloro-3-fluorophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Cyanophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Fluorophenyl)-2-(4-(3-methoxyphenyl)cyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Fluorophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2-(4-(2-methoxyphenyl)cyclohexyl)acetamide,
cis-2-(4-(2-Chloro-4-methoxyphenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide,
cis-2-(4-(2-Chloro-4-methoxyphenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide,
cis-2-(4-(4-Chloro-2-fluorophenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide,
trans-2-(4-(4-Chloro-2-fluorophenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide;
cis-2-(4-(4-Chloro-2-fluorophenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide,
trans-2-(4-(4-Chloro-2-fluorophenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide,
cis-2-(4-(4-Chloro-3-fluorophenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide,
trans-2-(4-(4-Chloro-3-fluorophenyl)cyclohexyl)-N-(4-chlorophenyl)acetamide;
cis-2-(4-(4-Chloro-3-fluorophenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide,
trans-2-(4-(4-Chloro-3-fluorophenyl)cyclohexyl)-N-(4-fluorophenyl)acetamide,
N-(4-Cyanophenyl)-2-(4-(2-fluoro-4-methoxyphenyl)cyclohexyl)acetamide,
N-(4-Fluorophenyl)-2-(4-(2-fluoro-4-methoxyphenyl)cyclohexyl)acetamide,
N-(4-Chlorophenyl)-2-(4-(2-fluoro-4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Chlorophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Cyanophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Fluorophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2-(4-(3-chloro-4-methoxyphenyl)cyclohexyl)acetamide,
cis-N-(4-Cyanophenyl)-2,2-di fluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2,2-difluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
cis-N-(4-Fluorophenyl)-2,2-difluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
trans-N-(4-Cyanophenyl)-2,2-difluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
cis-N-(4-Chlorophenyl)-2,2-difluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2,2-difluoro-2-(1-hydroxy-4-phenylcyclohexyl)acetamide,
trans-N-(4-Fluorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
trans-N-(4-Chlorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
trans-N-(4-Cyanophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
cis-N-(4-Fluorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
cis-N-(4-Cyanophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)acetamide;
cis-N-(4-Chlorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)propenamide;
cis-N-(4-Fluorophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)propenamide;
cis-N-(4-Cyanophenyl)-2-(1-hydroxy-4-phenylcyclohexyl)propenamide;
cis-N-(4-Cyanophenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)propenamide;
trans-N-(4-Cyanophenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)propenamide;
cis-N-(4-Fluorophenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)propenamide;
cis-N-(4-Chlorophenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)propenamide;
trans-N-(4-Chlorophenyl)-2-41,4)-4-(4-methoxyphenyl)cyclohexyl)propenamide;
cis-N-(4-Cyanophenyl)-2-((1,4)-4-phenylcyclohexyl)propenamide;
trans-N-(4-Cyanophenyl)-2-((1,4)-4-phenylcyclohexyl)propenamide;
cis-N-(4-Fluorophenyl)-2-((1,4)-4-phenylcyclohexyl)propenamide;
trans-N-(4-Fluorophenyl)-2-((1,4)-4-phenylcyclohexyl)propenamide;
cis-N-(4-Chlorophenyl)-241,4)-4-phenylcyclohexyl)propenamide;
trans-N-(4-Chlorophenyl)-241,4)-4-phenylcyclohexyl)propenamide;
N-(4-Chlorophenyl)-2-(4-fluoro-4-phenylcyclohexyl)acetamide;
(cis)-N-(4-Chlorophenyl)-2-(4-(2,4-dimethoxyphenyl)cyclohexyl)acetamide;
(trans)-N-(4-Chlorophenyl)-2-(4-(2,4-dimethoxyphenyl)cyclohexyl)-acetamide;
(cis)-N-(4-Cyanophenyl)-2-(4-(2,4-dimethoxyphenyl)cyclohexyl)acetamide;
(cis)-N-(4-Fluorophenyl)-2-(4-(2,4-dimethoxyphenyl)cyclohexyl)acetamide;
2-(4-(4-Acetamidophenyl)cyclohexyl)-N-(4-chlorophenyl)-acetamide;
2-(4-(4-A cetamidophenyl)cyclohexyl)-N-(4-fluorophenyl)-acetamide;
cis-2-(4-(4-Methoxyphenyl)cyclohexyl)-N-(4-(tetrahydro-2H-pyran-4-yl)phenyl) acetamide;
N-(4-Chlorophenyl)-2-(4-(4-hydroxyphenyl)cyclohexyl)acetamide;
(S)—N-(4-Cyanophenyl)-2-((1s,4r-4-phenylcyclohexyl)propenamide,
(R)—N-(4-Cyanophenyl)-2-((1s,4r)-4-phenylcyclohexyl)propenamide,
(R)—N-(4-Cyanophenyl)-2-((1s,4s)-4-(4-methoxyphenyl)cyclohexyl)propenamide,
2-(4-([1,1′-biphenyl]-3-yl)cyclohexyl)-N-(4-chlorophenyl) propenamide,
or a pharmaceutically acceptable salt, hydrate or solvate thereof.