US 11,931,733 B2
Device and method for repeatedly modifying the composition of a fluid
Martin Leuthold, Goettingen (DE); Alexander Helling, Ebergoetzen (DE); and Ulrich Grummert, Bad Sooden-Allendorf (DE)
Assigned to Sartorius Stedim Biotech GmbH, Goettingen (DE)
Filed by Sartorius Stedim Biotech GmbH, Goettingen (DE)
Filed on Jun. 4, 2021, as Appl. No. 17/339,891.
Application 17/339,891 is a continuation of application No. PCT/EP2019/083797, filed on Dec. 5, 2019.
Claims priority of application No. 10 2018 009 597.6 (DE), filed on Dec. 7, 2018.
Prior Publication US 2021/0291161 A1, Sep. 23, 2021
Int. Cl. B01L 3/00 (2006.01); B01D 61/14 (2006.01); G05D 21/00 (2006.01)
CPC B01L 3/502 (2013.01) [B01D 61/146 (2022.08); G05D 21/00 (2013.01); B01L 2200/0631 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0681 (2013.01); B01L 2400/06 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A device for repeatedly modifying a composition of a fluid, comprising:
a first module for modifying the composition of the fluid, a second module for modifying the composition of the fluid and a dwell module with an inlet and an outlet,
wherein the first module is connected in a fluid-conducting manner to the inlet of the dwell module and the outlet of the dwell module is connected in a fluid-conducting manner to the second module,
wherein at least one of the first module and the second module is a filter unit,
wherein the filter unit has:
at least one supply channel,
at least one first filter medium,
at least one retentate channel,
at least one second filter medium, and
at least one permeate channel,
arranged so that the first filter medium delimits the supply channel and the retentate channel from one another, and the second filter medium delimits the retentate channel and the permeate channel from one another,
wherein the supply channel is connected in a fluid-conducting manner to at least one inlet for a supply medium,
wherein the retentate channel is connected in a fluid-conducting manner to at least one inlet for the fluid and to at least one outlet for the fluid,
wherein the permeate channel is connected in a fluid-conducting manner to at least one outlet for a permeate, and wherein either:
(i) the dwell module defines a coherent volume internally subdivided by at least one subdividing element forming a non-linear fluid path, or
(ii) the dwell module comprises a plurality of flow channels arranged in parallel to one another and all connected in a fluid-conducting manner to the inlet of the dwell module and in a fluid-conducting manner to the outlet of the dwell module.